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Your search for “Therapy Target” returned 457 results

Closing the RNA Loop Holds Promise for More Stable, Effective RNA Therapies

…into circles could lead to more effective and long-lasting therapies, shows a study by UC San Diego researchers. The advance holds promise for a range of diseases, offering a more enduring alternative to existing RNA therapies, which often suffer from short-lived effectiveness in the body.

Novel Study Identifies Key Molecular Players in Rheumatoid Arthritis

Using a novel systems biology approach, scientists at UC San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis, a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.

Enzyme Controlling Metastasis of Breast Cancer Identified

Researchers at the University of California, San Diego School of Medicine have identified an enzyme that controls the spread of breast cancer. The findings, reported in the current issue of PNAS, offer hope for the leading cause of breast cancer mortality worldwide.

Progression of Lung Fibrosis Blocked in Mouse Model

…unknown causes, affect nearly five million people worldwide. No therapy is known to improve the health or survival of patients.

UC San Diego Chemists Take Aim at Drug Predictions

UC San Diego chemists offer new system to ease the synthesis and evaluation of the algorithms, the chemistry and the technology needed to predict the bound poses of ligands within a targeted protein—a necessity for designing new drugs.

Old Drugs Find New Target For Treating Brain Tumor

Scientists at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center, in collaboration with colleagues in Boston and South Korea, say they have identified a novel gene mutation that causes at least one form of glioblastoma (GBM), the most common type of malignant…

Organoids Derived From Gut Stem Cells Reveal Two Distinct Molecular Subtypes of Crohn’s Disease

UC San Diego researchers discover two distinct molecular subtypes of Crohn’s disease using patient-derived organoids, opening the door to personalized treatment for the chronic inflammatory bowel disease.

UC San Diego Research Funded By CIRM to Identify Potential Autism Drug Targets

A researcher at the University of California, San Diego School of Medicine is among principal investigators at 10 California institutions receiving Early Translational IV Research grants, totaling $40 million, approved today by the governing board of the California Institute for Regenerative Medicine (CIRM) at its meeting in San Diego.

Scientists Identify Promising New Approach for Immune System Defense against Cancer

Researchers have identified a promising new strategy to fight infections and cancer. They uncovered a novel function for a protein known as “Runx3” that is key to the development of killer T cells—immune cells important for fighting infections and cancer. The researchers believe Runx3, if properly directed, could be combined…

Protein Clumps in ALS Neurons Provide Potential Target for New Therapies

UC San Diego School of Medicine researchers identified chemical compounds that prevent stress-induced clumping of TDP-43 protein in ALS motor neurons grown in the lab — a starting point for new ALS therapeutics.