August 6, 2012
Researchers at the University of California, San Diego School of Medicine say neutrophils, an abundant type of white blood cell typically tasked with attacking bacteria and other foreign invaders, also plays an unexpected role in mediating insulin resistance – the central characteristic of type 2 diabetes, which afflicts an estimated…
August 13, 2019
UC San Diego researchers discovered that removing a single enzyme in mice dramatically boosts survival from sepsis, an often fatal over-reaction of the immune system to infection. The finding provides a new and unexpected therapeutic target for new drug development.
November 8, 2017
Chronic inflammation is known to drive many cancers, especially liver cancer. Researchers have long thought that’s because inflammation directly affects cancer cells, stimulating their division and protecting them from cell death. But University of California San Diego School of Medicine researchers have now found that chronic liver inflammation also promotes…
June 26, 2024
Engineers have developed a pill that releases microscopic robots, or microrobots, into the colon to treat inflammatory bowel disease (IBD). The experimental treatment, given orally, has shown success in mice. It significantly reduced IBD symptoms and promoted the healing of damaged colon tissue without causing toxic side effects.
August 5, 2013
A team of scientists, led by Napoleone Ferrara, MD, has shown for the first time that a signaling protein involved in inflammation also promotes tumor resistance to anti-angiogenic therapy.
January 12, 2017
…session of moderate exercise can also act as an anti-inflammatory. The findings have encouraging implications for chronic diseases like arthritis, fibromyalgia and for more pervasive conditions, such as obesity.
January 4, 2018
Researchers at UC San Diego have developed macrophage “nanosponges”—nanoparticles cloaked in the cell membranes of macrophages—that can safely remove sepsis-causing molecules from the bloodstream. In lab tests, these macrophage nanosponges improved survival rates in mice with sepsis.
October 15, 2015
…in skin fibrosis, a life-threatening disease characterized by the inflammation and hardening of skin tissue. The new study is the first to investigate the role of this molecule in skin fibrosis and paves the way toward new and improved therapies for the disease.
April 11, 2019
Treatment with a choline kinase inhibitor prompts immune cells to clear away damaged mitochondria, thus reducing NLRP3 inflammasome activation and preventing inflammation
December 20, 2023
In a groundbreaking development in the field of anti-acne therapies, a team of researchers has created an acne vaccine that, when used in a mouse acne model, neutralizes a specific variant of an enzyme produced by an acne-associated bacteria while leaving the healthy bacterial enzyme intact.
