Epigenetics Alters Genes in Rheumatoid Arthritis
July 3, 2012
…role in altering genes that could potentially contribute to inflammation and joint damage.
Your search for “Inflammation” returned 378 results
Newly Identified Target May Help with Drug Discovery for Chronic Inflammatory Diseases
July 25, 2018
In a study published online July 25 in the journal Nature, University of California San Diego School of Medicine researchers identified a signaling pathway that activates the NLRP3 inflammasome implicated in several severe chronic inflammatory disorders.
Study Finds that Fast-Moving Cells in the Human Immune System Walk in a Stepwise Manner
March 17, 2014
A team of biologists and engineers at the University of California, San Diego has discovered that white blood cells, which repair damaged tissue as part of the body’s immune response, move to inflamed sites by walking in a stepwise manner.
Immune Cells Infiltrating Tumors May Play Bigger Cancer Role Than Previously Thought
June 22, 2020
UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells’ response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.
Crohn’s Disease Research Bolstered With Grant from Helmsley Charitable Trust
August 23, 2023
A grant of nearly $3.5 million from The Leona M. and Harry B. Helmsley Charitable Trust is supporting research at UC San Diego to identify better, more targeted treatments for people living with Crohn’s disease.
The Connection Between Oxygen and Diabetes
June 5, 2014
Researchers at the University of California, San Diego School of Medicine have, for the first time, described the sequence of early cellular responses to a high-fat diet, one that can result in obesity-induced insulin resistance and diabetes. The findings also suggest potential molecular targets for preventing or reversing the process.
More Anti-inflammatory Genes Mean Longer Lifespans for Mammals
April 7, 2015
…the immune system — inflammation and chemically active molecules called reactive oxygen species that help fight infection, but also wreak molecular havoc, contributing to frailty, disability and disease. The CD33rSiglec family of proteins are known to help protect our cells from becoming inflammatory collateral damage, prompting researchers at the University…
Historical Disease Meets Modern Biology in New Faculty Member Cressida Madigan’s Lab
July 2, 2020
…perception of pain or inflammation in the brain? What’s the benefit to the microbe of doing that? Essentially, I’m studying a three-way interaction between microbes, the immune system and the nervous system. Q. Describe the targets of your research. A. The primary questions that my lab is investigating address two…
Blocking Tumor-Induced Inflammation Impacts Cancer Development
October 3, 2012
Researchers at the University of California, San Diego School of Medicine report the discovery of microbial–dependent mechanisms through which some cancers mount an inflammatory response that fuels their development and growth.
Researchers Reveal 3D Structure of Cell’s Inflammation Sensor and its Inhibitors
December 7, 2016
…fit together may better enable pharmaceutical companies to develop anti-inflammatory drugs that bind and inhibit CCR2 in a similar manner. The study is published December 7 by Nature.
