March 6, 2020
A team of chemists and biochemists at UC San Diego used a combination of computational simulations and experiments to deepen understanding of the latest genome editing technology.
June 28, 2017
Using a novel molecular dynamics method capable of capturing the motion of gyrating proteins at time intervals up to one thousand times greater than previous efforts, a team led by UC San Diego researchers has identified, for the first time, the myriad structural changes that activate and drive CRISPR-Cas9, the…
February 9, 2017
…in London and Singapore, have conducted novel whole genome sequencing of a family in which two of four children were affected by Kawasaki disease. They have identified plausible gene variants that predispose some children to developing the disease.
July 3, 2012
…the first time a significant portion of the functional sequences of the mouse genome, the most widely used mammalian model organism in biomedical research.
November 21, 2019
According to a new Cell study, extra DNA scooped up and copied alongside cancer-causing genes helps keep tumors going — elements that could represent new drug targets for brain tumors and other cancers notoriously difficult to treat.
January 25, 2017
In her first year as an assistant professor at UC San Diego, Computer Science and Engineering as well as Medicine professor Melissa Gymrek is already bringing honor to the institution. In its 2017 roster of top-notch young scientists, Forbes magazine included Gymrek among its top 30 researchers in the Science…
May 25, 2015
Researchers at University of California, San Diego School of Medicine and Moores Cancer Center have now identified six mRNA isoforms (bits of genetic material) produced by ovarian cancer cells but not normal cells, opening up the possibility that they could be used to diagnose early-stage ovarian cancer. What’s more, several…
April 19, 2018
…remaining risk: rare inherited variants in regions of non-coding DNA.
December 20, 2012
…the journal Cell on December 21, shows that the DNA sequence in some regions of the human genome is quite volatile and can mutate ten times more frequently than the rest of the genome. Genes that are linked to autism and a variety of other disorders have a particularly strong…
August 10, 2017
…be used to manipulate DNA. In 2016, University of California San Diego School of Medicine researchers repurposed the technique to track RNA in live cells in a method called RNA-targeting Cas9. In a study published August 10 in Cell, the team took RCas9 a step further: they corrected molecular mistakes…
