DNA Treatment Could Delay Paralysis That Strikes Nearly All Patients with ALS
March 16, 2023
UC San Diego researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.
Your search for “DNA Sequencing” returned 243 results
Bioengineering Study Finds Two-Cell Mouse Embryos Already Talking about Their Future
November 26, 2014
…which used single-cell RNA sequencing to look at every gene in the mouse genome, was published recently in the journal Genome Research. In addition, this group published a paper on analysis of ”time-course”single-cell data which is taken at precise stages of embryonic development in the journal of Proceedings of the…
Long-Reads and Powerful Algorithms Identify “Invisible” Microbes
January 3, 2022
Researchers have shown that highly accurate, long-read genomic sequencing technology (HiFi), combined with advanced algorithms, can differentiate between nearly identical organisms, allowing researchers to more completely catalogue microbial communities.
Extrachromosomal DNA is common in human cancer and drives poor patient outcomes
August 17, 2020
The multiplication of genes located in extrachromosomal DNA that have the potential to cause cancer drives poor patient outcomes across many cancer types, according to a Nature Genetics study published Aug. 17, 2020 by a team of researchers including the University of California San Diego.
Rare Genetic Mutations Linked To Bipolar Disorder
December 21, 2011
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, reports that abnormal sequences of DNA known as rare copy number variants, or CNVs, appear to play a significant role in the risk for early onset bipolar disorder.
Teaching Computers to Recognize Sick Guts: Machine-Learning and the Microbiome
January 12, 2017
A new proof-of-concept study by UC San Diego researchers succeeded in training computers to “learn” what a healthy versus an unhealthy gut microbiome looks like based on its genetic makeup.
$6M NIH Grant Launches UC San Diego Consortium to Study Insulin-Producing Cells
September 9, 2021
UC San Diego School of Medicine researchers will receive $6.4 million in National Institutes of Health grant funding to study how external signals and genetic variations influence the behavior of one cell type in particular: insulin-producing beta cells in the pancreas.
Genetic Changes that Cause Autism Are More Diverse Than Previously Thought
March 24, 2016
The types of gene mutations that contribute to autism are more diverse than previously thought, report researchers at University of California, San Diego School of Medicine in the March 24 online issue of The American Journal of Human Genetics. The findings, they say, represent a significant advance in efforts to…
Joint Resolution: A Link Between Huntington’s Disease and Rheumatoid Arthritis
May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common autoimmune disease that affects more than 1.3 million Americans.
These Mutations Could Be Key to Understanding How Some Harmful Conditions Develop
September 12, 2017
A team of researchers led by a bioinformatician at the University of California San Diego has developed a method to help determine whether certain hard-to-study mutations in the human genome, called short tandem repeats or microsatellites, are likely to be involved in harmful conditions. The team, which also includes scientists…
