February 6, 2020
Researchers from University of California San Diego School of Medicine have defined the most detailed list of genetic fingerprints of DNA-damaging processes that drive cancer development to date.
August 12, 2019
Biologists have developed the first system for determining gene expression based on machine learning. Considered a type of Rosetta Stone, the new method leverages algorithms trained on a set of known plant genes. The method carries implications across biology, from drug discovery to plant breeding.
October 27, 2014
A hinge in the RNA genome of the virus that causes hepatitis C works like a switch that can be flipped to prevent it from replicating in infected cells. Scientists have discovered that this shape is shared by several other viruses—among them one that kills cancer cells.
May 5, 2014
With accelerating development of personalized cancer treatments matched to a patient’s DNA sequencing, proponents say frontline physicians increasingly need help to maneuver through the complex genomic landscape to find the most effective, individualized therapy.
December 11, 2017
…have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer’s, Parkinson’s, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered which…
July 6, 2015
Using human tumor samples and mouse models, researchers at University of California, San Diego School of Medicine and Moores Cancer Center discovered that cancer stem cell properties are determined by epigenetic changes — chemical modifications cells use to control which genes are turned on or off.
October 6, 2021
In a special issue of Nature, UC San Diego researchers further refine the organization of cells within key regions of the mouse brain and the organization of transcriptomic, epigenomic and regulatory factors that provide these brain cells with function and purpose.
July 25, 2019
UC San Diego biochemists discovered a large-scale molecular movement associated with RNA catalysis that provides evidence for the origin of RNA splicing and its role in the diversity of life on Earth.
February 13, 2018
…carries genetic information from DNA to ribosomes where specifications of gene expression occur—the chemists were able to precisely trigger gene expressions at a specific time and place using laser light. This novel technique will ease future studies of individual protein functions in cells or tissues at different stages of biological…
October 12, 2021
Researchers at UC San Diego School of Medicine awarded $11.7 million by National Institutes of Health to identify genomic and socioeconomic factors contributing to health and disease in admixed individuals. The new center aims to bring the genomic revolution to all.
