April 25, 2012
University of California, San Diego scientists have used powerful computational tools and laboratory tests to discover new support for a once-marginalized theory about the underlying cause of Parkinson’s disease.
January 27, 2022
A study led by UC San Diego sheds light on why Alzheimer’s drugs so far have been ineffective at curing or reversing the disease. The researchers identify new targets for drug development and present a new method to screen drugs for treating Alzheimer’s disease.
February 1, 2024
UC San Diego scientists are working to flip the script on drug addiction with a $1.3 million grant from the W.M. Keck Foundation. Their new approach, called negative feedback chemogenetics, works by leveraging the body’s biochemical feedback processes to disrupt pathways associated with addiction.
November 28, 2013
Using quantitative models of bacterial growth, a team of UC San Diego biophysicists has discovered the bizarre way by which antibiotic resistance allows bacteria to multiply in the presence of antibiotics, a growing health problem in hospitals and nursing homes across the United States.
February 19, 2014
…of complex chemical systems that scientists can use to design new drugs, better chemicals, or improved enzymes for biofuels production.
May 6, 2024
Researchers from University of California San Diego have developed a new AI tool to that generate new drug candidates for cancer, which could help streamline the typically laborious drug discovery process.
January 26, 2015
…and help drive therapeutic drug development, researchers at University of California, San Diego School of Medicine developed 3D computer models that show exactly how two PLA2 enzymes extract their substrates from cellular membranes. The new tool is described in a paper published online the week of Jan. 26 by the…
June 27, 2019
UC San Diego chemists offer new system to ease the synthesis and evaluation of the algorithms, the chemistry and the technology needed to predict the bound poses of ligands within a targeted protein—a necessity for designing new drugs.
April 20, 2014
Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered a biomarker called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing…
January 20, 2021
UC San Diego study supports launch of Phase I clinical trial to test a designer DNA agent — an antisense oligonucleotide that targets a gene called IRF4 — in patients with multiple myeloma.
