September 5, 2016
Using a unique computational approach to rapidly sample, in millisecond time intervals, proteins in their natural state of gyrating, bobbing, and weaving, a research team from UC San Diego and Monash University in Australia has identified promising drug candidates that may selectively combat heart disease, from arrhythmias to cardiac failure.
April 17, 2012
Karl Y. Hostetler, MD, has been selected as the recipient of the 2012 Gertrude Elion Memorial Lecture Award by the International Society of Antiviral Research. Hostetler is a professor of medicine in the Divisions of Infectious Diseases and Endocrinology at the UC San Diego School of Medicine.
November 30, 2012
…transcription-factors (TFs) hierarchy. The findings could lead to new drug designs for mental disorders such as autism-spectrum disorders (ASD) and schizophrenia.
April 25, 2012
University of California, San Diego scientists have used powerful computational tools and laboratory tests to discover new support for a once-marginalized theory about the underlying cause of Parkinson’s disease.
January 27, 2022
A study led by UC San Diego sheds light on why Alzheimer’s drugs so far have been ineffective at curing or reversing the disease. The researchers identify new targets for drug development and present a new method to screen drugs for treating Alzheimer’s disease.
November 28, 2013
Using quantitative models of bacterial growth, a team of UC San Diego biophysicists has discovered the bizarre way by which antibiotic resistance allows bacteria to multiply in the presence of antibiotics, a growing health problem in hospitals and nursing homes across the United States.
February 19, 2014
…of complex chemical systems that scientists can use to design new drugs, better chemicals, or improved enzymes for biofuels production.
January 26, 2015
…and help drive therapeutic drug development, researchers at University of California, San Diego School of Medicine developed 3D computer models that show exactly how two PLA2 enzymes extract their substrates from cellular membranes. The new tool is described in a paper published online the week of Jan. 26 by the…
June 27, 2019
UC San Diego chemists offer new system to ease the synthesis and evaluation of the algorithms, the chemistry and the technology needed to predict the bound poses of ligands within a targeted protein—a necessity for designing new drugs.
April 20, 2014
Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered a biomarker called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing…
