February 1, 2024
UC San Diego scientists are working to flip the script on drug addiction with a $1.3 million grant from the W.M. Keck Foundation. Their new approach, called negative feedback chemogenetics, works by leveraging the body’s biochemical feedback processes to disrupt pathways associated with addiction.
March 19, 2012
Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing. Hepatitis C is a chronic infectious disease that affects some 170 million people worldwide and causes…
April 1, 2014
Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body.
November 19, 2020
…in Development of Flu Drugs Researchers demonstrate molecular binding mechanism that could change approach to designing influenza treatments There is no hole-in-one drug treatment when it comes to the flu, but that doesn’t stop scientists from trying to sink one. Especially since as many as one in five Americans gets…
March 26, 2020
…that can help researchers design new drugs and vaccines to combat the coronavirus Scientists are preparing a massive computer model of the coronavirus that they expect will give insight into how it infects in the body. They’ve taken the first steps, testing the first parts of the model and optimizing…
March 24, 2020
Researchers at four University of California Health medical centers have begun recruiting participants for a Phase II clinical trial to investigate the safety and efficacy of treating adult patients with COVID-19 with remdesivir, a drug that has shown promising activity against multiple viruses.
October 31, 2022
Computational chemistry affects everyday life more than most people might realize. It is used to develop drugs to treat diseases, generate data for environmental clean-up purposes, design solar energy technology, improve batteries, create enzymes to break down plastics and more.
March 6, 2018
The study, published in the March 5 online edition of the Proceedings of the National Academy of Sciences (PNAS), describes how the supercomputing power of Gordon, Comet, and GPU clusters, all based at the San Diego Supercomputer Center at UC San Diego, were used with improved accelerated molecular dynamics (aMD)…
November 14, 2011
…have identified a new drug discovery approach enabling the destruction of the most highly proliferative tumors. The discovery, published in the November 13 online issue of the journal Nature Medicine, points to an effective, alternative method for killing fast-growing cancer cells without causing some of the negative effects of current…
October 9, 2014
…unreleased proprietary data for drug discovery through a new $3.7 million effort funded by the National Institutes for Health. The project, which is led by UC San Diego principal investigators Rommie Amaro, Victoria Feher and Dr. Michael K. Gilson, includes a major subcontract to Rutgers University, directed by Dr. Stephen…
