DNA Treatment Could Delay Paralysis That Strikes Nearly All Patients with ALS
March 16, 2023
UC San Diego researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.
Your search for “designer drugs” returned 450 results
Biologists Engineer Algae to Make Complex Anti-Cancer ‘Designer’ Drug
December 10, 2012
…algae to produce a complex and expensive human therapeutic drug used to treat cancer. Their achievement opens the door for making these and other “designer” proteins in larger quantities and much more cheaply than can now be made from mammalian cells.
RNA-Based Drugs Give More Control Over Gene Editing
November 16, 2015
In just the past few years, researchers have found a way to use a naturally occurring bacterial system known as CRISPR/Cas9 to inactivate or correct specific genes in any organism. CRISPR/Cas9 gene editing activity runs continuously, though, leading to risk of additional editing at unwanted sites. Now, researchers at University…
UC San Diego Biophysicists Examine Development of Antibiotic Resistance
December 5, 2013
…antibiotics and developing new drugs against bacteria already resistant to conventional drug treatments. But understanding how bacteria grow and evolve drug resistance could also help stop its spread by allowing scientists to target the process of evolution itself. “Understanding how bacteria harboring antibiotic resistance grow in the presence of antibiotics…
SDSC Team Models Potential SARS-CoV2 Protease Inhibitors for COVID-19
December 1, 2020
A team of SDSC researchers recently created a pharmacophore model and conducted data mining of the database of drugs approved by the U.S. Federal Drug Administration (FDA) to find potential inhibitors of papain-like protease of SARS-CoV2, one of the main viral proteins responsible for COVID-19
Clinical Trial Evaluates Synthetic Cannabinoid as Brain Cancer Treatment
September 25, 2012
Researchers at University of California, San Diego Moores Cancer Center are evaluating the safety and tolerability of a synthetic cannabinoid called dexanabinol (ETS2101). Delivered as a weekly intravenous infusion, the drug is being tested in patients with all forms of brain cancer, both primary and metastatic.
A New Approach to Faster Anticancer Drug Discovery
March 13, 2012
Tracking the genetic pathway of a disease offers a powerful, new approach to drug discovery, according to scientists at the University of California, San Diego School of Medicine who used the approach to uncover a potential treatment for prostate cancer, using a drug currently marketed for congestive heart failure.
Discovery Provides Blueprint for New Drugs That Can Inhibit Hepatitis C Virus
March 19, 2012
Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing. Hepatitis C is a chronic infectious disease that affects some 170 million people worldwide and causes…
Good Vibrations: Using Light-Heated Water to Deliver Drugs
April 1, 2014
Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body.
Don Cleveland Wins a Trifecta of Recognition
January 31, 2023
In the span of just a few weeks, Don Cleveland, a leading researcher in the study of neurodegenerative diseases like ALS and Alzheimer’s, has received three major awards.
