DNA Treatment Could Delay Paralysis That Strikes Nearly All Patients with ALS
March 16, 2023
UC San Diego researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.
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Don Cleveland Wins a Trifecta of Recognition
January 31, 2023
In the span of just a few weeks, Don Cleveland, a leading researcher in the study of neurodegenerative diseases like ALS and Alzheimer’s, has received three major awards.
Biologists Engineer Algae to Make Complex Anti-Cancer ‘Designer’ Drug
December 10, 2012
…algae to produce a complex and expensive human therapeutic drug used to treat cancer. Their achievement opens the door for making these and other “designer” proteins in larger quantities and much more cheaply than can now be made from mammalian cells.
Artificial Intelligence Aids Discovery of Super Tight-Binding Antibodies
January 31, 2023
UC San Diego scientists developed an artificial intelligence tool that could accelerate the development of new high affinity antibody drugs.
RNA-Based Drugs Give More Control Over Gene Editing
November 16, 2015
In just the past few years, researchers have found a way to use a naturally occurring bacterial system known as CRISPR/Cas9 to inactivate or correct specific genes in any organism. CRISPR/Cas9 gene editing activity runs continuously, though, leading to risk of additional editing at unwanted sites. Now, researchers at University…
UC San Diego Biophysicists Examine Development of Antibiotic Resistance
December 5, 2013
…antibiotics and developing new drugs against bacteria already resistant to conventional drug treatments. But understanding how bacteria grow and evolve drug resistance could also help stop its spread by allowing scientists to target the process of evolution itself. “Understanding how bacteria harboring antibiotic resistance grow in the presence of antibiotics…
SDSC Team Models Potential SARS-CoV2 Protease Inhibitors for COVID-19
December 1, 2020
A team of SDSC researchers recently created a pharmacophore model and conducted data mining of the database of drugs approved by the U.S. Federal Drug Administration (FDA) to find potential inhibitors of papain-like protease of SARS-CoV2, one of the main viral proteins responsible for COVID-19
Clinical Trial Evaluates Synthetic Cannabinoid as Brain Cancer Treatment
September 25, 2012
Researchers at University of California, San Diego Moores Cancer Center are evaluating the safety and tolerability of a synthetic cannabinoid called dexanabinol (ETS2101). Delivered as a weekly intravenous infusion, the drug is being tested in patients with all forms of brain cancer, both primary and metastatic.
A New Approach to Faster Anticancer Drug Discovery
March 13, 2012
Tracking the genetic pathway of a disease offers a powerful, new approach to drug discovery, according to scientists at the University of California, San Diego School of Medicine who used the approach to uncover a potential treatment for prostate cancer, using a drug currently marketed for congestive heart failure.
Researchers Unveil New Approach to Flip the Script on Drug Addiction
February 1, 2024
UC San Diego scientists are working to flip the script on drug addiction with a $1.3 million grant from the W.M. Keck Foundation. Their new approach, called negative feedback chemogenetics, works by leveraging the body’s biochemical feedback processes to disrupt pathways associated with addiction.
