Science & Environment

UC San Diego Physicist Named a 2018 Simons Investigator

The stuff the universe is made of. The origins of life. Dreams. Consciousness. Multiple universes. These are among the biggest questions in science. University of California San Diego Professor of Physics Kenneth Intriligator addresses challenging topics like these, and his theoretic efforts gained the attention of the Simons Foundation, which named him one of its 2018 Simons Investigators, announced in the July 10 edition of the “New York Times.”

UC San Diego Biologists Discover Process That Neutralizes Tumors

Researchers discovered an unexpected twist in the battle versus tumors. Tumors employ a protein called PD-L1 to blind T cells from functioning. PD-L1 protects tumors through a “molecular brake” known as PD-1. Researchers have found that some tumor cells display not only their PD-L1 weapon, but also the PD-1 brake, essentially becoming a neutralizing function. The unexpected mechanism could help determine whether a cancer patient will respond to immunotherapy.

Scientists Present New Cold Facts about Antifreeze Proteins

Many insects and animals have special proteins that act like car antifreeze to prevent ice from forming and spreading in their bodies amidst harsh winter temperatures. Scientists know about these antifreeze proteins (AFPs), but not so much about the mechanisms that make them work. Chemistry researchers at the University of California San Diego and the University of Utah, however, share new cold facts about AFP function in their July 9 article published in the Proceedings of the National Academy of Sciences (PNAS). Their research results could impact a variety of industrial and natural processes, including cloud formation, as well as future scientific studies.

Crystal Structure Reveals How Curcumin Impairs Cancer

Through x-ray crystallography and kinase-inhibitor specificity profiling, University of California San Diego School of Medicine researchers, in collaboration with researchers at Peking University and Zhejiang University, reveal that curcumin, a natural occurring chemical compound found in the spice turmeric, binds to the kinase enzyme dual-specificity tyrosine-regulated kinase 2 (DYRK2) at the atomic level. This previously unreported biochemical interaction of curcumin leads to inhibition of DYRK2 that impairs cell proliferation and reduces cancer burden.

New Dean Selected to Lead UC San Diego’s Division of Biological Sciences

UC San Diego has selected Kit Pogliano, a professor of molecular biology, as its new dean for the Division of Biological Sciences. Pogliano was selected after a national search and will begin her new appointment on Sept. 15, 2018. She is the fourth dean of the division and its first female leader. She will lead a renowned division that consistently ranks among the world’s best in biology research and education.

New Treatment Option Available for Men Suffering from Benign Prostatic Hyperplasia

Physicians at UC San Diego Health are now offering prostate artery embolization as a new treatment option for men with benign prostatic hyperplasia, or an enlarged prostate. The minimally invasive procedure is an alternative to surgery, with no hospital stay, little operative pain and lower cost.