November 9, 2015
…of the National Academy of Sciences, uses a semiconductor sequencing platform to identify small chromosomal deletions or duplications, such as occur in Cri du Chat Syndrome and DiGeorge Syndrome, with a simple blood test from the expectant mother.
November 7, 2018
…the dynamic research area of epigenetics—adding chemical tags to DNA and histone proteins to alter cell functions without changing DNA sequence. Understanding the fundamental principles of how epigenetic information is transduced in the cell eventually could lead to developing new drugs for fighting diseases like cancer.
October 18, 2011
…to help manage ever-growing data sets used in next-generation DNA sequencing.
July 3, 2012
…usually implicated in cancer and in fetal development, called DNA methylation, in the progression of rheumatoid arthritis (RA). They found that epigenetic changes due to methylation play a key role in altering genes that could potentially contribute to inflammation and joint damage.
November 20, 2019
UC San Diego researchers describe how circular extrachromosomal DNA in cancer cells boosts aggressiveness and resistance to therapies.
December 19, 2013
Researchers at the University of California, San Diego School of Medicine, with colleagues in The Netherlands and United Kingdom, have produced the first map detailing the network of genetic interactions underlying the cellular response to ultraviolet (UV) radiation.
June 27, 2017
…and Sun Yat-sen Cancer Center in China, report that DNA methylation can provide effective markers for at least four major cancers, not only correctly differentiating malignant tissues from normal, but also providing information on prognosis and survival.
August 26, 2015
Using DNA sequencing, researchers have accurately painted a clear picture of fish spawning activities in a marine protected area (MPA) and have created a baseline for continuing studies on the effects of climate variability on fish populations.
September 18, 2013
Sequencing the DNA of an organism, whether human, plant, or jellyfish, has become a straightforward task, but assembling the information gathered into something coherent remains a massive data challenge.
October 31, 2017
Interdisciplinary team of UC San Diego researchers develop a way to very accurately sequence and haplotype genomes from single human cells. The breakthrough appears in the Proceedings of the National Academy of Sciences.
