August 25, 2014
…to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature. These findings have been published online as a priority report in the journal Oncotarget.
February 18, 2015
…code. Yet different types of cells read the same DNA in widely different ways, influenced by chemical chemical tags that modify the genetic material without changing the underlying DNA sequence. Scientists today announced significant progress in the unraveling of the code that guides those differences, a body of information they…
November 12, 2013
…California, San Diego have generated the most complete genome sequences from single E. coli cells and individual neurons from the human brain. The breakthrough comes from a new single-cell genome sequencing technique that confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters.
October 31, 2016
UC San Diego’s Computer Science and Engineering department and Illumina Inc. co-sponsored DNA Day 2016, a day-long workshop featuring talks and cutting-edge bioinformatics and genomics research, including several speakers with dual appointments in CSE and the UC San Diego School of Medicine.
August 22, 2018
In a paper published this week in the journal PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Spain and Finland, describe for the first time how one type of RNA polymerase gets stalled by DNA lesions caused by exposure to ultraviolet (UV) light.
September 12, 2016
A team led by researchers at the University of California San Diego has captured in step-by-step atomic detail the surgical editing of DNA strands by CRISPR-Cas9, the innovative gene-splicing technology that in recent years has transformed the field of genetic engineering.
February 16, 2016
…developed a method that greatly improves researchers’ ability to sequence the DNA of organisms that can’t be cultured in the lab, such as microbes living in the human gut or bacteria living in the depths of the ocean. They published their work in the Feb. 1 issue of Nature Methods.
July 27, 2017
…electron microscopic imaging tools and a selective stain for DNA to visualize the three-dimensional structure of chromatin — a complex of molecules that helps pack six feet of DNA into each cell nucleus, construct chromosomes and control gene expression and DNA replication.
August 9, 2012
…a new algorithm to sequence organisms’ genomes from a single cell faster and more accurately. The new algorithm, called SPAdes, can be used to sequence bacteria that can’t be submitted to standard cloning techniques—what researchers refer to as the dark matter of life, from pathogens found in hospitals, to bacteria…
November 12, 2021
UC San Diego researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.
