Macrophages are immune cells that are supposed to protect the body from infection by viruses and bacteria. Yet Zika virus preferentially infects these cells. Researchers at University of California San Diego School of Medicine have now unraveled how the virus shuts down the genes that make macrophages function as immune cells.
Kenneth (Ken) Bowles, a computer science pioneer and professor emeritus at the University of California San Diego, passed away on Aug. 15, 2018 in Solana Beach, California. He was 89. Bowles gained world renown for initiating and leading a largely student-driven project that culminated in the creation of the UCSD Pascal programming system in the late 1970s, which included a programming language, an operating system and a whole suite of other tools. UCSD Pascal influenced many aspects of computing that are now ubiquitous, including modern PCs and Macs as well as Sun Microsystem’s Java language.
Progress in treating chronic illness, where the cause of the problem is often unknown, has lagged. Chronic conditions like cancer, diabetes and cardiovascular disease defy easy explanation, let alone remedy. In a new paper, a researcher at University of California San Diego School of Medicine, posits that chronic disease is essentially the consequence of the natural healing cycle becoming blocked, specifically by disruptions at the metabolic and cellular levels.
Writing in the current online issue of the journal Stem Cells and Development, researchers at University of California San Diego School of Medicine describe development of a rapid, cost-effective method to create human cortical organoids directly from primary cells.
University of California San Diego and Deerfield Management announce today the creation of Poseidon Innovation, LLC to advance disease-curing therapeutics. Through Deerfield’s $65-million commitment in Poseidon, UC San Diego investigators will have the funding and support to weather risky early-stage processes and expedite the drug-development cycle, allowing patients to receive treatment faster.
Engineers have developed neutrophil “nanosponges” that can safely absorb and neutralize a variety of proteins that play a role in the progression of rheumatoid arthritis. Injections of these nanosponges effectively treated severe rheumatoid arthritis in two mouse models. Administering the nanosponges early on also prevented the disease from developing. The nanosponges are nanoparticles of biodegradable polymer coated with the cell membranes of neutrophils, a type of white blood cell.
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