Through x-ray crystallography and kinase-inhibitor specificity profiling, University of California San Diego School of Medicine researchers, in collaboration with researchers at Peking University and Zhejiang University, reveal that curcumin, a natural occurring chemical compound found in the spice turmeric, binds to the kinase enzyme dual-specificity tyrosine-regulated kinase 2 (DYRK2) at the atomic level. This previously unreported biochemical interaction of curcumin leads to inhibition of DYRK2 that impairs cell proliferation and reduces cancer burden.
Physicians at UC San Diego Health are now offering prostate artery embolization as a new treatment option for men with benign prostatic hyperplasia, or an enlarged prostate. The minimally invasive procedure is an alternative to surgery, with no hospital stay, little operative pain and lower cost.
Ceramides—waxy, oily lipid molecules that affect biological function like insulin resistance, gene regulation and tumor suppression—could be applied to new cancer treatments…if only scientists could study them directly in living organisms. Tackling this task with a brand of chemistry that addresses biological challenges, University of California San Diego Professor Neal Devaraj produced research results that confront the limitations of studying ceramides.
Scientists have long pondered how non-living materials coalesced into the earliest life forms on Earth. Nearly 60 years ago Stanley Miller and Harold Urey, founding professors of the physical sciences at the University of California San Diego, established a tradition of working to answer questions about life’s molecular origins. Professor Neal Devaraj continues that UC San Diego legacy by using chemistry to solve questions in biology, while also developing new tools that uniquely perform tasks within living cells. For his inventive work, the Blavatnik Family Foundation and the New York Academy of Sciences have announced Devaraj as the 2018 Blavatnik National Laureate in Chemistry.
With microbial resistance to antibiotics growing into a major global health crisis, researchers at University of California San Diego School of Medicine, in collaboration with national research institutions and private industry, are leveraging hard-won expertise to exploit a natural viral enemy of pathogenic bacteria, creating North America’s first Center for Innovative Phage Applications and Therapeutics (IPATH).
Human activities—from growing rice and burning coal or wood, to driving cars and testing nuclear missiles—have impacted the Earth’s atmosphere over time. Cleansing the Earth’s environment is of growing interest in the new era of humanity, unofficially called the Anthropocene epoch. To better understand the impact of the human biogeochemical footprint on Earth, scientists at the University of California San Diego are literally climbing mountains to study the planet’s sulfur cycle—an agent in cardiovascular fitness and other human health benefits and resources.
