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News Archive - Scott LaFee

A New Approach to Faster Anticancer Drug Discovery

March 13, 2012

Tracking the genetic pathway of a disease offers a powerful, new approach to drug discovery, according to scientists at the University of California, San Diego School of Medicine who used the approach to uncover a potential treatment for prostate cancer, using a drug currently marketed for congestive heart failure.

Embryonic Development Protein Active in Cancer Growth

March 5, 2012

A team of scientists at the University of California, San Diego Moores Cancer Center has identified a novel protein expressed by breast cancer cells – but not normal adult tissues – that could provide a new target for future anti-cancer drugs and treatments.

Express Yourself: How Zygotes Sort Out Imprinted Genes

February 16, 2012

Researchers at the Ludwig Institute for Cancer Research, the University of California, San Diego School of Medicine and the Toronto Western Research Institute peel away some of the enduring mystery of how zygotes or fertilized eggs determine which copies of parental genes will be used or ignored.

Researchers Induce Alzheimer’s Neurons From Pluripotent Stem Cells

January 25, 2012

Led by researchers at the University of California, San Diego School of Medicine, scientists have, for the first time, created stem cell-derived, in vitro models of sporadic and hereditary Alzheimer’s disease (AD), using induced pluripotent stem cells from patients with the much-dreaded neurodegenerative disorder.

New Fluorescent Dyes Highlight Neuronal Activity

January 25, 2012

Researchers at the University of California, San Diego School of Medicine have created a new generation of fast-acting fluorescent dyes that optically highlight electrical activity in neuronal membranes. The work is published in this week’s online Early Edition of the Proceedings of the National Academy of Sciences.

New Test Spots Early Signs of Inherited Metabolic Disorders

January 9, 2012

A team of scientists, led by researchers at the University of California, San Diego School of Medicine and Zacharon Pharmaceuticals, have developed a simple, reliable test for identifying biomarkers for mucopolysaccharidoses (MPS), a group of inherited metabolic disorders that are currently diagnosed in patients only after symptoms have become serious and the damage possibly irreversible.

DNA Mismatch Repair Happens Only During A Brief Window of Opportunity

December 22, 2011

In eukaryotes – the group of organisms that include humans – a key to survival is the ability of certain proteins to quickly and accurately repair genetic errors that occur when DNA is replicated to make new cells.

Rare Genetic Mutations Linked To Bipolar Disorder

December 21, 2011

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, reports that abnormal sequences of DNA known as rare copy number variants, or CNVs, appear to play a significant role in the risk for early onset bipolar disorder.

Stem Cell ‘Collaboratory’ Opens on UC San Diego Campus

December 6, 2011

Stem cells are tiny things, microscopic in fact. It’s the power of their pluripotency, their ability to become any kind of cell in the human body (and thus potentially fix almost any kind of human ailment) that makes them huge in the future of medicine.

Old Drugs Find New Target For Treating Brain Tumor

November 18, 2011

Scientists at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center, in collaboration with colleagues in Boston and South Korea, say they have identified a novel gene mutation that causes at least one form of glioblastoma (GBM), the most common type of malignant brain tumor.
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