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News Archive - Scott LaFee

Of Mice and Men, a Common Cortical Connection

November 16, 2011

A new study using magnetic resonance imaging data of 406 adult human twins affirms the long-standing idea that the genetic basis of human cortical regionalization – the organization of the outer brain into specific functional areas – is similar to and consistent with patterns found in other mammals, indicating a common conservation mechanism in evolution.

Blood Pressure and Stroke Risk Gets More Complicated

November 15, 2011

For patients who have suffered an ischemic stroke, traditional treatment prescribes keeping subsequent blood pressure levels as low as possible to reduce the risk of another stroke. A new international study, however, suggests this conventional approach may not be helpful, and could actually increase recurrent stroke risk – at least in the first few months after the first event.

New Way to Target – And Kill – Proliferating Tumors

November 14, 2011

Researchers at the University of California, San Diego School of Medicine and the UC San Diego Moores Cancer Center have identified a new drug discovery approach enabling the destruction of the most highly proliferative tumors. The discovery, published in the November 13 online issue of the journal Nature Medicine, points to an effective, alternative method for killing fast-growing cancer cells without causing some of the negative effects of current therapies.

Knocking Out Key Protein in Mice Boosts Insulin Sensitivity

November 10, 2011

By knocking out a key regulatory protein, scientists at the University of California, San Diego School of Medicine and the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland dramatically boosted insulin sensitivity in lab mice, an achievement that opens a new door for drug development and the treatment of diabetes.

Non-Coding RNA Relocates Genes When It’s Time To Go To Work

November 10, 2011

Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in the November 9 issue of the journal Cell, researchers at the University of California, San Diego School of Medicine say this process is even more complex than previously thought, with regulated genes actually relocated to other, more conducive places in the cell nucleus.

Neurological Disorder Impacts Brain Cells Differently

November 9, 2011

In a paper published in the November 9 issue of The Journal of Neuroscience, researchers at the University of California, San Diego School of Medicine and University of Washington describe in deeper detail the pathology of a devastating neurological disorder, but also reveal new cellular targets for possibly slowing its development.

Hippocampus Plays Bigger Memory Role Than Previously Thought

November 1, 2011

Human memory has historically defied precise scientific description, its biological functions broadly but imperfectly defined in psychological terms.

Sexual Selection by Sugar Molecule Helped Determine Human Origins

October 10, 2011

Researchers at the University of California, San Diego School of Medicine say that losing the ability to make a particular kind of sugar molecule boosted disease protection in early hominids, and may have directed the evolutionary emergence of our ancestors, the genus Homo.

Immune Mechanism Blocks Inflammation Generated by Oxidative Stress

October 5, 2011

Conditions like atherosclerosis and age-related macular degeneration (AMD) – the most common cause of blindness among the elderly in western societies – are strongly linked to increased oxidative stress, the process in which proteins, lipids and DNA damaged by oxygen free radicals and related cellular waste accumulate, prompting an inflammatory response from the body’s innate immune system that results in chronic disease.

Fatty Acid Test: Why Some Harm Health, But Others Help

September 29, 2011

A major risk factor for cardiovascular disease, type 2 diabetes and other health- and life-threatening conditions, obesity is epidemic in the United States and other developed nations where it’s fueled in large part by excessive consumption of a fat-rich “Western diet.”
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