September 10, 2018
Macrophages are immune cells that are supposed to protect the body from infection by viruses and bacteria. Yet Zika virus preferentially infects these cells. Researchers at University of California San Diego School of Medicine have now unraveled how the virus shuts down the genes that make macrophages function as immune…
December 3, 2018
Following the FDA’s approval of chimeric antigen receptor (CAR) T-cell therapies for the treatment of certain types of non-Hodgkin lymphomas, UC San Diego Health was the first medical center in San Diego to be certified to offer this type of immunotherapy outside of a clinical trial.
March 9, 2021
Bioengineers at UC San Diego and San Diego State University have discovered a key feature that allows cancer cells to break from typical cell behavior and migrate away from stiffer tissue in a tumor, shedding light on the process of metastasis and offering possible new targets for cancer therapies.
December 11, 2017
…“Runx3” that is key to the development of killer T cells—immune cells important for fighting infections and cancer. The researchers believe Runx3, if properly directed, could be combined with other approaches to help T cells recognize and destroy tumor cells and enhance vaccine efficacy.
July 30, 2014
Embryonic stem cells can develop into a multitude of cells types. Researchers would like to understand how to channel that development into the specific types of mature cells that make up the organs and other structures of living organisms.
May 21, 2015
Using human embryonic stem cells, researchers at University of California, San Diego School of Medicine and Moores Cancer Center and Sanford-Burnham Medical Research Institute created a model that allows them to track cellular behavior during the earliest stages of human development in real-time. The model reveals, for the first time,…
September 28, 2017
…can reprogram white blood cells to ignore a self-defense signaling mechanism that cancer cells use to survive and spread in the body. Researchers say the advance could lead to a new method of re-engineering immune cells to fight cancer and infectious diseases. The team successfully tested this method in a…
May 20, 2019
UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.
September 21, 2017
…the development of immune cells called T cells. These areas activate a change in the 3D structure of DNA that brings together crucial elements necessary for T cell formation. This “big bang” discovery may be unfolding throughout the animal and plant kingdoms as well as aid in combating diseases such…
May 8, 2017
Engineers at the University of California San Diego have developed biomimetic bone tissues that could one day provide new bone marrow for patients needing transplants.
