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Your search for “T cells” returned 881 results

Boosting Immune Cell Memory to Improve Vaccines and Cancer Immunotherapy

August 28, 2017

…of Medicine have discovered that drugs that activate the cells’ proteasome, or recycling center, tip the balance in favor of memory CD8+ T cells. This approach could be used to improve how well vaccines and immunotherapies work and how long they last.

T Cells Can Activate Themselves to Fight Tumors

May 8, 2023

UC San Diego scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.

CAR-T Immunotherapies May Have a New Player

June 29, 2018

Emerging CAR-T immunotherapies leverage modified versions of patient’s T-cells to target and kill cancer cells. In a new study, researchers at University of California San Diego School of Medicine and University of Minnesota report that similarly modified natural killer (NK) cells derived from human induced pluripotent stem cells (iPSCs) also…

Controlling CAR T Cells with Light Selectively Destroys Skin Tumors in Mice

February 19, 2020

UC San Diego bioengineers developed a control system that could make CAR T-cell therapy safer and more powerful when treating cancer. By programming CAR T cells to switch on when exposed to blue light, the researchers controlled the cells to destroy skin tumors in mice without harming healthy tissue

“Open” Stem Cell Chromosomes Reveal New Possibilities for Diabetes

April 2, 2015

Cells of the intestine, liver and pancreas are difficult to produce from stem cells. Writing in Cell Stem Cell April 2, researchers at University of California, San Diego School of Medicine have discovered that chromosomes in laboratory stem cells open slowly over time, in the same sequence that occurs during…

Cancer Cells Co-opt Immune Response to Escape Destruction

December 18, 2012

Researchers at the University of California, San Diego School of Medicine report that tumor cells use stress signals to subvert responding immune cells, exploiting them to actually boost conditions beneficial to cancer growth.

Drug-Light Combo Could Offer Control Over CAR T-Cell Therapy

October 15, 2019

UC San Diego bioengineers are a step closer to making CAR T-cell therapy safer, more precise and easy to control. They developed a system that allows them to select where and when CAR T cells get turned on so that they destroy cancer cells without harming normal cells.

Researchers Block Pathway to Cancer Cell Replication

July 3, 2012

…the self-renewing leukemia initiating cells, often referred to as cancer stem cells. In such cancers, the cells lie dormant for a time, only to later begin cloning, resulting in a return and metastasis of the disease. One such type of cancer is called pediatric T cell acute lymphoblastic leukemia, or…

Putting ‘Super’ in Natural Killer Cells

June 11, 2020

Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells — a type of immune cell — with measurably stronger activity against a form of leukemia, both in vivo and in vitro.

Immune Cells Anchored in Tissues Offer Unique Defenses Against Pathogens and Cancers

June 29, 2022

Researchers are expanding their understanding of unique immune “memory” cells equipped to remember malicious invaders. They developed an atlas that describes tissue-resident memory cells in diverse settings, boosting prospects for new immune defense strategies at vulnerable infection sites.

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