November 21, 2017
…surrounding a tumor can trigger metastatic behavior in cancer cells. Specifically, when tumor cells are confined in a dense environment, the researchers found that they turn on a specific set of genes and begin to form structures that resemble blood vessels.
March 17, 2020
UC San Diego researchers have developed a computational tool that makes modeling and simulation of complex cellular processes more true to life. The tool, dubbed GAMer 2, simplifies the process of using realistic cell geometries in mathematical models.
March 5, 2018
…that can turn genes on and off in mammalian cells. This is the most efficient so-called “optogenetic switch” activated by red and far-red light that has been successfully designed and tested in animal cells—and it doesn’t require the addition of sensing molecules from outside the cells.
May 17, 2016
…immediately emerges when ERK1/2 is halted, thus allowing tumor cell proliferation to continue.
January 23, 2014
…is also activated in surrounding blood vessels, enabling cancer cells to spread into the bloodstream.
November 17, 2014
Researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells. Once inside, cellular machinery converts these disguised drug precursors — called siRNNs — into active RNAi drugs.
March 27, 2013
…School of Medicine, says a key protein in Schwann cells performs a critical, perhaps overarching, role in regulating the recovery of peripheral nerves after injury. The discovery has implications for improving the treatment of neuropathic pain, a complex and largely mysterious form of chronic pain that afflicts over 100 million…
July 21, 2016
…of mutated genes and drugs that together kill cancer cells. The study, published July 21 in Molecular Cell, uncovered 172 new combinations that could form the basis for future cancer therapies.
January 13, 2016
Researchers at University of California, San Diego School of Medicine and Rady Children’s Hospital-San Diego have created the first stem cell-derived in vitro cellular model of a rare, but devastating, neurodegenerative condition called Cockayne syndrome (CS).
October 20, 2014
UC San Diego Sanford Stem Cell Clinical Center is pushing therapeutic stem cell-based science out of the laboratory and closer to real-world medical applications. The unprecedented trials involve potential therapies for spinal cord injuries, Type 1 diabetes and chronic lymphocytic leukemia.
