Novel Antisense Drug Shows Promise in Slowing Fatty Liver Disease
June 16, 2020
A first-in-class clinical trial suggests a novel treatment measurably slowed progression of non-alcoholic fatty liver disease to its more progressive and deadly form.
Your search for “Fatty liver disease” returned 65 results
Selective, Toxin-Bearing Antibodies Could Help Treat Liver Fibrosis
July 12, 2021
UC San Diego researchers discovered that immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis, in mouse models of human disease.
UC San Diego Launches New Nonalcoholic Fatty Liver Disease Research Center
February 8, 2016
…children – have nonalcoholic fatty liver disease (NAFLD), a chronic condition that can lead to cirrhosis, liver cancer and liver failure. Combining a diverse array of basic science, biomarkers, imaging and clinical efforts, University of California, San Diego School of Medicine has launched a new NAFLD Research Center to better…
Peptide Improves Glucose and Insulin Sensitivity, Lowers Weight in Mice
February 7, 2018
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School of Medicine researchers.
Study: Potential New Treatment Identified for Liver Disease
June 26, 2023
Researchers with UC San Diego School of Medicine identified a potential new drug that improved liver fibrosis in patients with NASH by 27%.
Universal Gut Microbiome-Derived Signature Predicts Cirrhosis
June 30, 2020
UC San Diego School of Medicine researchers report that stool microbiomes of NAFLD patients are distinct enough to potentially be used to accurately predict which persons with NAFLD are at greatest risk for having cirrhosis.
Unexpected Activity of Two Enzymes Helps Explain Why Liver Cancer Drugs Fail
December 13, 2016
…enzymes can lead to liver disease and cancer in mice. In human liver tumors, they found that deficiencies in these two enzymes, Shp2 and Pten, are associated with poor prognosis. The study, published December 13 by Cell Reports, provides a new understanding of liver cancer development, new therapeutic approach and…
How Chronic Inflammation Tips the Balance of Immune Cells to Promote Liver Cancer
November 8, 2017
…drive many cancers, especially liver cancer. Researchers have long thought that’s because inflammation directly affects cancer cells, stimulating their division and protecting them from cell death. But University of California San Diego School of Medicine researchers have now found that chronic liver inflammation also promotes cancer by suppressing immunosurveillance —…
Antibody Blocks Inflammation, Protects Mice from Hardened Arteries and Liver Disease
June 6, 2018
…from arterial plaque formation, hardening of the arteries and liver disease, and prolonged their lives.
Movement Toward a Poop Test for Liver Cirrhosis
March 29, 2019
In a study of people with nonalcoholic fatty liver disease and their twins and other close relatives, UC San Diego researchers were able to diagnose liver cirrhosis simply by analyzing a person’s stool microbes.
