Popularly dubbed “the book of life,” the human genome is extraordinarily difficult to read. In a paper published in the July 1, 2012 issue of the journal Nature, researchers at the Ludwig Institute for Cancer Research and the University of California, San Diego School of Medicine open the book further, mapping for the first time a significant portion of the functional sequences of the mouse genome, the most widely used mammalian model organism in biomedical research.
Health & Behavior
Research suggests that patients with leukemia sometimes relapse because standard chemotherapy fails to kill the self-renewing leukemia initiating cells, often referred to as cancer stem cells. In such cancers, the cells lie dormant for a time, only to later begin cloning, resulting in a return and metastasis of the disease. One such type of cancer is called pediatric T cell acute lymphoblastic leukemia, or T-ALL, often found in children, who have few treatment options beyond chemotherapy.
A first-time workshop highlighting the latest advances in the Kepler Scientific Workflow System brought together researchers and computational scientists to discuss a wide array of innovative uses for the software application, ranging from data curation of natural science collections to facilitating nuclear fusion computations.
“Good times for a good cause” is the philosophy of the annual Brian Schultz Memorial Golf Classic, taking place Saturday, August 11 at the Rancho Bernardo Inn. Featuring live entertainment and great food—in addition to golf—the tournament raises funds for cancer research at the UC San Diego Moores Cancer Center.
A team of doctors and scientists, led by researchers at the University of California, San Diego School of Medicine and the Howard Hughes Medical Institute, say de novo somatic mutations in a trio of genes that help regulate cell size and proliferation are likely culprits for causing hemimegalencephaly, though perhaps not the only ones.
Psoriasis is an autoimmune disorder in which skin cells proliferate out of control. For some hard-to-heal wounds, the problem is just the opposite: Restorative skin cells don’t grow well or fast enough. In a paper published in the June 21, 2012 issue of Immunity, researchers at the University of California, San Diego School of Medicine describe a molecule that may lead to new treatments for both problems.
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