Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.
Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer’s, Parkinson’s, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered which of these subtypes are most susceptible to common risk factors for different brain diseases.
Researchers have identified a promising new strategy to fight infections and cancer. They uncovered a novel function for a protein known as “Runx3” that is key to the development of killer T cells—immune cells important for fighting infections and cancer. The researchers believe Runx3, if properly directed, could be combined with other approaches to help T cells recognize and destroy tumor cells and enhance vaccine efficacy.
Researchers at University of California San Diego School of Medicine have found a genetic signature for delay discounting — the tendency to undervalue future rewards — that overlaps with attention-deficit/hyperactivity disorder (ADHD), smoking and weight.
Scientists have developed a new algorithm that can identify distinct click patterns among millions of clicks in recordings of wild dolphins, whose communication serves as a sentinel of ocean ecosystem health.
Don Cleveland spends much of his time ruminating on the faulty molecular mechanisms that drive diseases like amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) and Huntington’s. James McKernan explores the world of birational geometry. Joanne Chory digs into the secrets of plant life.
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