School of Medicine

The Latest

Double Enzyme Hit May Explain Common Cancer Drug Side Effect

Many leukemias are caused by loss of the enzyme Pten. Some anti-leukemia treatments work by inhibiting another enzyme called Shp2. Researchers at University of California, San Diego School of Medicine have now found that mice lacking both of these enzymes can’t produce and sustain enough red blood cells. The study, published October 12 by PNAS, helps explain why anemia is a common side effect of anti-cancer drugs that target enzymes involved in tumor growth.

A Pediatric Cancer Drug Three Decades in the Making

By the age of 4, Matthew Haemsch had undergone 16 rounds of chemotherapy and a surgery to remove a cancerous tumor on his adrenal gland. Yet, his small body remained riddled with a rare pediatric cancer.

UC San Diego Researchers Team Up with Illumina to Speed-Read Your Microbiome

University of California, San Diego School of Medicine’s Rob Knight, PhD, and his team built a microbiome analysis platform called QIIME (pronounced “chime” and short for “Quantitative Insights Into Microbial Ecology”). This software will now be more readily accessible to hundreds of thousands of researchers around the world through BaseSpace, a cloud-based app store offered by Illumina, a San Diego-based company that develops life science tools for the analysis of genetic variation.

NIH Establishes 4D Nucleome Research Centers and Organizational Hub at UC San Diego

Under its new 4D Nucleome Program, the National Institutes of Health (NIH) Common Fund has awarded three grants totaling more than $30 million over five years to multidisciplinary teams of researchers at University of California, San Diego.

Online E-cigarette Vendors Engage Customers Using Popular Internet Tools

First introduced in the United States in 2007, electronic cigarettes have risen dramatically in part because they are popularly considered safer and more socially acceptable than combustible cigarettes and because there are fewer restrictions on their purchase and use. A study by University of California, San Diego School of Medicine researchers, published in the journal Drug and Alcohol Dependence, points to aggressive online marketing tactics that make purchasing e-cigarettes easy for all ages.

Fatty Liver Disease and Scarring Have Strong Genetic Component

Researchers at the University of California, San Diego School of Medicine say that hepatic fibrosis, which involves scarring of the liver that can result in dysfunction and, in severe cases, cirrhosis and cancer, may be as much a consequence of genetics as environmental factors.