March 8, 2018
March 8, 2018 —
Through a randomized, double-blind, placebo-controlled phase II clinical trial, researchers at University of California San Diego School of Medicine report that small doses of NGM282, a non-tumorigenic variant of an endocrine gastrointestinal hormone, can significantly and rapidly decrease liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The findings, they say, represent an important proof-of-concept for the compound as there are currently no Food and Drug Administration-approved treatments for NAFLD and NASH.
March 7, 2018
March 7, 2018 —
UC San Diego Health is the first hospital in California to use the fifth generation troponin test to diagnose heart attack. Approved in the United States in 2017, the more sensitive test can detect heart attack within an hour, as opposed to three to six hours.
March 6, 2018
March 6, 2018 —
The study, published in the March 5 online edition of the Proceedings of the National Academy of Sciences (PNAS), describes how the supercomputing power of Gordon, Comet, and GPU clusters, all based at the San Diego Supercomputer Center at UC San Diego, were used with improved accelerated molecular dynamics (aMD) or Gaussian aMD (GaMD) to simulate the merger of a G-protein “mimetic nanobody” to a G-protein-coupled receptor (GPCR), the largest and most diverse group of membrane receptors in animals, plants, fungi, and protozoa.
March 5, 2018
March 5, 2018 —
On March 12, 2018, UC San Diego Health will welcome its first patients to the Koman Family Outpatient Pavilion. Located on the La Jolla campus, the new 156,000-square-foot facility represents the most recent addition to the university’s world-class medical campus. In the past five years, UC San Diego Health has invested more than $1.3 billion dollars in patient care facilities for the community.
March 5, 2018
March 5, 2018 —
For the first time, an international team of scientists, led by researchers at University of California San Diego School of Medicine, have determined that an Alzheimer’s disease (AD) polygenic risk score can be used to correctly identify adults with mild cognitive impairment (MCI) who were only in their 50s. MCI is considered a precursor to AD.
March 5, 2018
March 5, 2018 —
UC San Diego School of Medicine researchers developed a visible neural network and used it to build DCell, a virtual model of a functioning brewer’s yeast cell. To do this, they amassed all knowledge of cell biology in one place and created a hierarchy of these cellular components.
February 28, 2018
February 28, 2018 —
Science continues to peel away layers of the skin microbiome to reveal its protective properties. In a study published in Science Advances on February 28, University of California San Diego School of Medicine researchers report a potential new role for some bacteria on the skin: protecting against cancer.
February 27, 2018
February 27, 2018 —
Writing in the February 27 online issue of Science Signaling, researchers at University of California San Diego School of Medicine and Moores Cancer Center describe how a signaling protein that normally suppresses tumors can be manipulated (or re-programmed) by growth factors, turning it into a driver of malignant growth and metastasis.
February 27, 2018
February 27, 2018 —
A new computational resource called Recon3D provides a 3D view of genes, proteins and metabolites involved in human metabolism. Researchers used the tool to map disease-related mutations on proteins and also probed how genes and proteins change in response to certain drugs. The work provides a better understanding of disease-causing mutations and could enable researchers to discover new uses for existing drug treatments.
February 26, 2018
February 26, 2018 —
Led by researchers at University of California San Diego School of Medicine, a diverse team of neuroscientists and surgeons successfully grafted human neural progenitor cells into rhesus monkeys with spinal cord injuries. The grafts not only survived, but grew hundreds of thousands of human axons and synapses, resulting in improved forelimb function in the monkeys.
