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Visualizing a Key Step in How an NRPS Enzyme Produces an Antibiotic

Nonribosomal peptide synthetase (NRPS) enzymes are essential in creating important medications, such as penicillin and cyclosporine. Because of their large size, complex design and changing shapes, NRPS enzymes are difficult to study. In recent years, the lab of UC San Diego Professor of Chemistry and Biochemistry Michael Burkart has developed crosslinking tools to trap the enzyme at specific steps, freezing them in place, making them easier to visualize.

This New Advanced Method Produces Highly Realistic Simulations of Fluid Dynamics

Computer scientists at the University of California San Diego have developed a groundbreaking method for generating highly realistic computer-generated images of fluid dynamics, in elements such as smoke.

Scientists Unveil Surprising Human vs Mouse Differences in a Major Cancer Immunotherapy Target

Much of our knowledge of the protein PD-1, a leading cancer treatment target, comes from studies in mice. In a comprehensive assessment of PD-1, researchers have found that PD-1 in mice is significantly weaker than the human version, providing new information on how cancer treatments are developed.

Bionic Hand Sparks Resilience in Patient After Electrocution Accident

UC San Diego Health rehabilitation and prosthesis training help patient thrive with use of bionic hand after electrocution accident.

Enzyme Promoting Tumor Growth and Spread in Pancreatic Cancer Identified

An enzyme called MICAL2 promotes tumor growth and metastasis in the most common form of pancreatic cancer, according to a new study by UC San Diego School of Medicine researchers.

A “Ticking Time Bomb” for Liver Cancer

UC San Diego Scientists have revealed new insights into the origin of liver cancer and, more broadly, on the effects of a high-fat diet on our DNA.

Expanse Supercomputer to Expand Training for Chemistry Faculty, Students Nationwide

Sonoma State University Chemistry Professor and Chair Mark J. Perri has been awarded nearly $1M from the U.S. National Science Foundation to enhance ChemCompute, a free online platform he created for undergraduate students to perform advanced computational chemistry experiments.

A Legacy of Innovation, Compassion, and Leadership in Spine Surgery and Beyond

With a penchant for math and science, Steven R. Garfin, M.D., always figured he would do something related to science, but as an undergraduate student at the University of Minnesota, he had no idea how his career would turn out or the incredible impact that he would have on thousands of lives.

UC San Diego Undergraduate Research Students Use Data Science to Address Housing and Food Insecurity

At the Halıcıoğlu Data Science Institute (HDSI), part of the School of Computing, Information and Data Sciences (SCIDS) at UC San Diego, students in the Undergraduate Research Scholarship Program aim to address critical local challenges through data-driven research.

UC San Diego Electrical Engineering Professor Honored by Schmidt Sciences for AI Research

University of California San Diego electrical and computer engineering professor Yuanyuan Shi has been named a 2024 AI2050 Early Career Fellow by Schmidt Sciences. This honor recognizes Shi’s pioneering work in developing AI and control models for sustainable energy systems–particularly, AI-driven building control systems designed to optimize indoor air quality while reducing energy consumption.

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