October 26, 2021
University of California San Diego researchers describe how a pair of fundamental genetic and cellular processes — aneuploidy and unfolded protein response — are exploited by cancer cells to promote tumor survival and growth.
November 7, 2016
…high altitude while others don’t, researchers at University of California San Diego School of Medicine studied red blood cells derived from representatives of both groups living in the Andes Mountains. The study reveals that high-altitude, low-oxygen dwellers prone to chronic mountain sickness produce massive amounts of red blood cells thanks…
August 30, 2023
Immunologists have uncovered new approaches to enhance protection from tumors and infections. They have revealed new insights into the metabolism of specialized cells of the immune system known as tissue-resident CD8 T cells and how they could be enhanced as immune defense weapons against tumors.
March 25, 2015
…control switch for the unfolded protein response (UPR), a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).
May 18, 2018
…slow down human heart cells growing in a dish on command — simply by shining a light on them and varying its intensity. The cells are grown on a material called graphene, which converts light into electricity, providing a more realistic environment than standard plastic or glass laboratory dishes.
August 11, 2014
During pregnancy, certain hormones trigger specialized mammary stem cells to create milk-producing cells essential to lactation. Scientists at the University of California, San Diego School of Medicine and Moores Cancer Center have found that mammary stem cells associated with the pregnant mammary gland are related to stem cells found in…
December 28, 2022
UC San Diego study reveals critical insights into the complex biology of tissue-specific T cells, paving the way for a new branch of precision therapeutics in immunity, autoimmunity, and cancer.
November 16, 2015
Peptides promise to be useful drugs, but they’re too easily digested and can’t get into cells without help. Chemists at UC San Diego now show that peptides can be protected from digestion and delivered into cells without changing their biological function by rearranging them into dense brushes.
June 22, 2020
UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells’ response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.
December 1, 2017
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers investigating novel stem cell-based treatments for acute myeloid leukemia or AML.
