Scientists Discover a New Signaling Pathway and Design a Novel Drug for Liver Fibrosis
April 25, 2024
Scientists from the University of California San Diego discovered a novel signaling pathway in liver cells, leading to a treatment for fibrosis.
Your search for “Liver fibrosis” returned 47 results
Researchers Illuminate Key Role of NOX Proteins in Liver Disease
July 29, 2015
Researchers at the University of California, San Diego School of Medicine have demonstrated a direct connection between two signaling proteins and liver fibrosis, a scarring process underlying chronic liver disease, the 12th leading cause of death in the United States.
Diet Plays Critical Role in NASH Progressing to Liver Cancer in Mouse Model
June 1, 2021
Researchers at University of California San Diego School of Medicine found in a mouse model that when fed a Western diet rich in calories, fat and cholesterol, the mice progressively became obese, diabetic and developed NASH, which progressed to HCC, chronic kidney and cardiovascular disease.
New Drug Successfully Halts Fibrosis in Animal Model of Liver Disease
August 7, 2012
A study published in the online journal Hepatology reports a potential new NADPH oxidase (NOX) inhibitor therapy for liver fibrosis, a scarring process associated with chronic liver disease that can lead to loss of liver function.
Math Equation Predicts and Detects Liver Cancer
December 16, 2019
University of California San Diego School of Medicine and Moores Cancer Center researchers developed a math equation to predict and detect liver cancer and identified when healthy cells become cancerous.
Selective, Toxin-Bearing Antibodies Could Help Treat Liver Fibrosis
July 12, 2021
UC San Diego researchers discovered that immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis, in mouse models of human disease.
Fatty Liver Disease and Scarring Have Strong Genetic Component
October 1, 2015
Researchers at the University of California, San Diego School of Medicine say that hepatic fibrosis, which involves scarring of the liver that can result in dysfunction and, in severe cases, cirrhosis and cancer, may be as much a consequence of genetics as environmental factors.
Liver Fibrosis ‘Off Switch’ Discovered in Mice
January 23, 2020
UC San Diego School of Medicine researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen — providing a new therapeutic target for liver fibrosis.
Progression of Lung Fibrosis Blocked in Mouse Model
October 5, 2011
…from use of the anti-cancer chemotherapy drug Bleomycin. Pulmonary fibrosis caused by this drug, as well as Idiopathic Pulmonary Fibrosis (IPF) from unknown causes, affect nearly five million people worldwide. No therapy is known to improve the health or survival of patients.
Scarring Cells Revert To Inactive State As Liver Heals
May 7, 2012
…– cells that produce the fibrous scarring in chronic liver injury – revert to an inactive phenotype as the liver heals. The discovery in mouse models could ultimately help lead to new human therapies for reversing fibrosis in the liver, and in other organs like the lungs and kidneys.
