New Mouse Model Points to Therapy for Liver Disease
August 18, 2014
…both the development of NASH and its progression to liver cancer.
Your search for “Liver Disease” returned 203 results
Lactating Mice Pass along Common Antimicrobial to Pups, Initiating Liver Damage
July 27, 2022
In mouse studies, UC San Diego researchers report that lactating mothers expose their feeding pups to triclosan, an antimicrobial commonly used in consumer products, resulting in early signs of liver damage.
Universal Gut Microbiome-Derived Signature Predicts Cirrhosis
June 30, 2020
UC San Diego School of Medicine researchers report that stool microbiomes of NAFLD patients are distinct enough to potentially be used to accurately predict which persons with NAFLD are at greatest risk for having cirrhosis.
Novel Antisense Drug Shows Promise in Slowing Fatty Liver Disease
June 16, 2020
A first-in-class clinical trial suggests a novel treatment measurably slowed progression of non-alcoholic fatty liver disease to its more progressive and deadly form.
Peptide Improves Glucose and Insulin Sensitivity, Lowers Weight in Mice
February 7, 2018
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School of Medicine researchers.
Intestinal Fungi Worsen Alcoholic Liver Disease
May 22, 2017
Liver cirrhosis is the 12th leading cause of mortality worldwide and approximately half of those deaths are due to alcohol abuse. Yet apart from alcohol abstinence, there are no specific treatments to reduce the severity of alcohol-associated liver disease. Researchers at University of California San Diego School of Medicine and…
Antimicrobial Soap Additive Worsens Fatty Liver Disease in Mice
November 23, 2020
Triclosan, an antimicrobial found in many soaps and other household items, worsens fatty liver disease in mice fed a high-fat diet.
UC San Diego Superfund Research Program Receives $15 Million Grant Renewal
May 22, 2012
The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, has renewed funding for the Superfund Research Program (SRP) at the University of California, San Diego. Over the next five years, the $15 million grant will fund continued research on the molecular and genetic consequences…
Scarring Cells Revert To Inactive State As Liver Heals
May 7, 2012
…– cells that produce the fibrous scarring in chronic liver injury – revert to an inactive phenotype as the liver heals. The discovery in mouse models could ultimately help lead to new human therapies for reversing fibrosis in the liver, and in other organs like the lungs and kidneys.
Programming probiotics for early detection of liver cancer
June 1, 2015
…new method for detecting liver cancer metastases in mice. The approach uses over-the-counter probiotics genetically programmed to produce signals easily detectable in urine when liver cancer metastases are present. The results of the new study, published in the May 27 issue of Science Translational Medicine, indicate that genetically-programmed probiotics may…
