CIRM Grant to Fund Proposed Stem Cell Trials for ALS
March 17, 2016
…human embryonic stem cell-based therapy to rescue and restore neurons devastated by amyotrophic lateral sclerosis or ALS.
Your search for “Motor neurons” returned 73 results
Motor Cortex Shown to Play Active Role in Learning Movement Patterns
May 4, 2014
UC San Diego neurobiologists discovered that the motor cortex of the brain plays an active role in learning new motor movements. In a series of experiments using mice, the researchers showed in detail how those movements are learned over time.
Protein Clumps in ALS Neurons Provide Potential Target for New Therapies
July 1, 2019
UC San Diego School of Medicine researchers identified chemical compounds that prevent stress-induced clumping of TDP-43 protein in ALS motor neurons grown in the lab — a starting point for new ALS therapeutics.
DNA Treatment Could Delay Paralysis That Strikes Nearly All Patients with ALS
March 16, 2023
UC San Diego researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.
When Water Temperatures Change, the Molecular Motors of Cephalopods Do Too
June 8, 2023
Working with live squid hatchlings at Scripps Institution of Oceanography, UC San Diego scientists find the animals can tune their proteome on the fly in response to changes in ocean temperature via the unique process of RNA recoding. The findings inspire new questions about basic protein function.
ALS Study Reveals Role of RNA-Binding Proteins
October 20, 2016
Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases are hereditary, a significant number of them are caused by mutations that affect proteins that bind RNA, a type of genetic material. University of California San Diego School of Medicine researchers studied several ALS cases with a mutation in a…
Key Pathway Leading to Neurodegeneration in Early Stages of ALS Identified
November 8, 2024
Researchers at UC San Diego identify a key pathway leading to neurodegeneration in early stages of ALS, hinting at the potential for short-circuiting the progression of the fatal disease if diagnosed early.
Longer, Intense Rehabilitation Boosts Recovery after Brain Injury
February 22, 2016
Cognitive and functional recovery after a stroke or traumatic injury requires intense rehabilitative therapy to help the brain repair and restructure itself. New findings by researchers at University of California, San Diego School of Medicine report that not only is rehabilitation vital but that a longer, even more intense period…
Mutant Protein in Muscle Linked to Neuromuscular Disorder
April 16, 2014
…a new study published in the online issue of Neuron, a team of scientists at the University of California, San Diego School of Medicine say novel mouse studies indicate that mutant protein levels in muscle cells are fundamentally involved in SBMA, suggesting an alternative and promising new avenue of treatment.
Neurological Disorder Impacts Brain Cells Differently
November 9, 2011
In a paper published in the November 9 issue of The Journal of Neuroscience, researchers at the University of California, San Diego School of Medicine and University of Washington describe in deeper detail the pathology of a devastating neurological disorder, but also reveal new cellular targets for possibly slowing its…
