UC San Diego researchers report using native bacteria in mice as the chassis for delivering transgenes capable of inducing persistent and potentially even curative therapeutic changes in the gut and reversing disease pathologies.
It’s a summer morning at La Jolla Shores and Robert O’Brien, a junior at Princeton University who is spending his summer at UC San Diego, is surfing—for science. He is participating in the Smartfin research project, which aims to improve the collection of oceanographic data near the shore.
It was a typical morning for Mike West, one that usually started with a quick shave before getting ready for work. However, this specific morning, he felt something unusual: a small, but hard lump just under his skin on his throat. West decided to call his doctor’s office.
Scientists are using new technologies to obtain unprecedented looks inside viruses and their unique abilities to infect and destroy bacteria. Using cryo-EM and other technologies, they found that jumbo phage cells feature a compartment that is surprisingly similar to the nucleus of human cells.
Battery researchers and other engineers from UC San Diego, with collaboration from the LG Energy Solution, outline three categories of engineering challenges that must be solved in order to transition all-solid-state batteries from the laboratory toward large-scale industrial manufacturing.
Researchers report that a gene therapy approach, developed at UC San Diego measurably delayed disease onset in humanized mouse and rat models of familial ALS, an inherited form of the disease that runs in families.
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