In a paper published online in Cancer Cell, scientists at the University of California, San Diego School of Medicine describe a novel mouse model that closely resembles human NASH and use it to demonstrate that interference with a key inflammatory protein inhibits both the development of NASH and its progression to liver cancer.
In a paper published online this week in Nature, researchers at the University of California, San Diego School of Medicine elaborate upon a crucial signaling pathway and the role of key proteins, which may help clear the way to generate HSCs from human pluripotent precursors, similar to advances with other kinds of tissue stem cells.
Our immune system copes with a multitude of threats using a mix-and-match system to create millions of different antibodies.
Oncologists at UC San Diego Moores Cancer Center are the first in San Diego to meld MRI technology with a traditional ultrasound prostate exam to create a three-dimensional map of the prostate that allows physicians to view growths that were previously undetectable.
Bioengineers at the University of California, San Diego have proven that when it comes to guiding stem cells into a specific cell type, the stiffness of the extracellular matrix used to culture them really does matter. When placed in a dish of a very stiff material, or hydrogel, most stem cells become bone-like cells. By comparison, soft materials tend to steer stem cells into soft tissues such as neurons and fat cells. The research team, led by bioengineering professor Adam Engler, also found that a protein binding the stem cell to the hydrogel is not a factor in the differentiation of the stem cell as previously suggested. The protein layer is merely an adhesive, the team reported Aug. 10 in the advance online edition of the journal Nature Materials.
Benefunder, a San Diego-based philanthropic research funding platform for higher education institutions, and the University of California, San Diego, recognized as one of the top 15 research universities worldwide, have signed a Memorandum of Understanding (MOU) to embark on a two-year pilot program. The long-term goal of the partnership between UC San Diego and Benefunder is to allow junior and senior faculty in diverse disciplines to create funding relationships with private supporters from across the country, and generate one-time and recurring donations to fund their work and vision.
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