Supercomputer Simulations Reveal New “Achilles heel” in Dengue Virus
By stretching the amount of time proteins can be simulated in their natural state of wiggling and gyrating, a team of researchers at Colorado State University -- using supercomputers at the San Diego Supercomputer Center at UC San Diego and the Pittsburgh Supercomputing Center -- has identified a critical protein structure that could serve as a molecular Achilles heel able to inhibit the replication of dengue virus and potentially other flaviviruses such as West Nile and Zika virus.