UC San Diego researchers discovered that removing a single enzyme in mice dramatically boosts survival from sepsis, an often fatal over-reaction of the immune system to infection. The finding provides a new and unexpected therapeutic target for new drug development.
Biologists have developed the first system for determining gene expression based on machine learning. Considered a type of Rosetta Stone, the new method leverages algorithms trained on a set of known plant genes. The method carries implications across biology, from drug discovery to plant breeding.
UC San Diego engineers have developed the thinnest optical device in the world: a waveguide that is three layers of atoms thin. The work is a proof of concept for scaling down optical devices to sizes that are orders of magnitude smaller than today’s devices.
The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor’s root, according to a new UC San Diego School of Medicine study published in Science Translational Medicine.
In a Phase III clinical trial, the drug volanesorsen significantly reduced blood fat (triglyceride) levels in participants with a rare disease called familial chylomicronemia syndrome; finding could also help inform better prevention methods and treatments for many types of heart disease.
The heart transplant program at UC San Diego Health has demonstrated the best one-year survival rate for patients in the United States among health care providers with a volume of more than 50 heart transplants per year, according to the Scientific Registry of Transplant Recipients.
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