Using fragments of circulating tumor DNA in blood, University of California San Diego School of Medicine researchers were able to identify theoretically targetable genetic alterations in 66 percent of patients with cancer of unknown primary (CUP), a rare disease with seven to 12 cases per 100,000 people each year.
QI Innovation Space member CARI Therapeutics has received a grant from the National Institutes of Health to collaboratively develop a biosensor that will detect the presence of opioids in patients in recovery.
An international team of scientists, led by University of California San Diego School of Medicine researchers, has created a human stem cell-based model of a rare, but devastating, inherited neurological autoimmune condition called Aicardi-Goutieres Syndrome (AGS). In doing so, the team was able to identify unusual and surprising underlying genetic mechanisms that drive AGS and test strategies to inhibit the condition using existing drugs.
Until recently, CRISPR-Cas9 gene editing could only be used to manipulate DNA. In 2016, University of California San Diego School of Medicine researchers repurposed the technique to track RNA in live cells in a method called RNA-targeting Cas9. In a study published August 10 in Cell, the team took RCas9 a step further: they corrected molecular mistakes that lead to microsatellite repeat expansion diseases, which include a type of ALS and Huntington's disease.
Microbiome researchers Rob Knight, PhD, University of California San Diego, Jeffrey Gordon, MD, Washington University School of Medicine in St. Louis, and Norman Pace, PhD, University of Colorado Boulder, will share this year’s Massry Prize, splitting the $200,000 honorarium. These researchers lead a field that works to produce a detailed understanding of microbiomes and methods for manipulating them for the benefit of human and environmental health.
UC San Diego Health and its medical and surgical specialties have been recognized as among the best in the nation by U.S. News & World Report for 2017-18. The annual “Best Hospitals” rankings distinguish hospitals that excel in treating the most challenging health conditions.
Independent, March 10
The San Diego Union-Tribune, March 9
The New York Times, March 9
U.S. News & World Report, March 4
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