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What Powered the Earth’s Earliest Life?

Early biological systems that could generate guanosine‑triphosphate (GTP) from prebiotic chemicals would gain a crucial advantage toward self‑replication. Now researchers from the UC San Diego report a version of an RNA enzyme (ribozyme) that makes GTP synthesis more efficient than its predecessor.

Gene Therapy Approach Reduces Muscle Spasticity After Chronic Spinal Cord Injury

New research suggests that a single administration of spinal segment-targeted gene therapy may provide a long-lasting strategy for reducing muscle spasticity caused by spinal cord injury and potentially other neurological conditions associated with abnormal muscle tone.

UC San Diego Study Uncovers Molecular “Shield” Behind Cancer Immunotherapy Resistance

UC San Diego researchers discovered that blocking microRNA-25 reshapes the tumor immune environment and improves responses to cancer immunotherapy.

Naturally Occurring Molecule May Help Outsmart Melanoma

Researchers from UC San Diego have uncovered a new possibility for treating melanoma, and it's something we have in our bodies already.

Poor Sleep Tied to Alzheimer’s Risk in Older Women

Sleep complaints may be an early warning sign of Alzheimer’s disease risk in older women. Sleep complaints may serve as a low-cost, early warning sign of Alzheimer’s risk and a potential target for prevention efforts.

Teens View Cannabis as Less Harmful Than Alcohol, Vapes and Cigarettes

Adolescents in California consistently perceive cannabis as less harmful than other commonly used substances, according to a new study analyzing data from two large statewide school surveys.

Water Molecules Found to Actively Drive Gene Transcription Process

Water molecules play an active, essential role in gene transcription, helping RNA polymerase II carry out the chemical steps needed to read DNA and build RNA.

How Does Turbulence Spread?

Researchers observed turbulence in a pure environment without external interference. They discovered a sharp front separating turbulence from non-turbulent fluid, agreeing with earlier theory. However, their data about turbulence decay were not consistent with other theories.

First Large‑scale Survey Estimates that 2.8% of U.S. Population Used Psilocybin in the Past Year

An analysis of the first national survey of psilocybin use suggests that 2.8% of Americans over the age of 12 have used the drug in the past year, with implications for clinical practice.

Why Some Brains with Alzheimer’s Stay Sharp

UC San Diego researchers uncovered why some people stay cognitively healthy despite Alzheimer’s-related brain changes, identifying a key pathway that may guide earlier detection and prevention.

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