July 13, 2016
…colleagues across the nation and world, have created a “mini-brain” model, derived from persons with a particular form of idiopathic ASD characterized by over-sized brains, revealing a defective molecular pathway during brain development that results in early neuronal overgrowth and dysfunctional cortical networks.
November 8, 2011
A study by researchers at the University of California, San Diego Autism Center of Excellence shows that brain overgrowth in boys with autism involves an abnormal, excess number of neurons in areas of the brain associated with social, communication and cognitive development.
March 22, 2012
…young autism patients genetic mechanisms involved in abnormal early brain development and overgrowth that occurs in the disorder. The findings suggest novel genetic and molecular targets that could lead to discoveries of new prevention strategies and treatment for the disorder.
August 7, 2013
…and an enzyme that, when combined, trigger the progressive cell degeneration and death characteristic of AD.
September 27, 2021
Researchers describe how withdrawal from nicotine, methamphetamine and cocaine alters the functional architecture and patterns in the brains of mice, compared to control animals, a key to developing addiction treatments.
February 18, 2021
UC San Diego researchers have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer’s disease or Mild Cognitive Impairment, a condition that often precedes full-blown dementia.
October 18, 2017
Modeling the interplay between neurons and astrocytes derived from children with Autism Spectrum Disorder (ASD), researchers at University of California San Diego School of Medicine, with colleagues in Brazil, say innate inflammation in the latter appears to contribute to neuronal dysfunction in at least some forms of the disease.
June 24, 2016
…to identify different subtypes of neurons in the human brain. The research lays the groundwork for “mapping” the gene activity in the human brain and could help provide a better understanding of brain functions and disorders, including Alzheimer’s, Parkinson’s, schizophrenia and depression.
August 9, 2023
Promising preclinical results from UC San Diego show hematopoietic stem cell therapy was effective in rescuing memory loss, neuroinflammation and beta amyloid build-up in a mouse model of Alzheimer’s disease.
September 22, 2016
…years in support of his studies on how bacterial cells communicate with each other via electrical signals, similar to the way neurons transmit messages in the brain.
