Culture Clash: How Stem Cells Are Grown Affects Their Genetic Stability
February 25, 2015
…the first time that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.
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State Stem Cell Agency Awards $4M for Blood Cancer Immunotherapy at UC San Diego
November 24, 2021
The California Institute for Regenerative Medicine (CIRM) approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T-cell therapy from the laboratory into the clinic.
UC San Diego Receives $9 Million in Grants to Pinpoint Cellular Cause of Type 1 Diabetes
August 13, 2019
UC San Diego School of Medicine has been awarded $9 million to fund research projects using human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes aimed at identifying the cellular actions leading to disease onset.
CIRM Approves New Funding to UC San Diego Researchers Fighting Zika Virus and Cancer
January 20, 2017
…treatments for Zika virus infections and the use of stem cell-derived natural killer (NK) cells to target ovarian cancer and other malignancies.
Clinical Study Suggests the Origin of Glioblastoma Subtypes
May 4, 2016
Researchers at University of California San Diego School of Medicine have demonstrated that distinct types of glioblastoma, the most common form of brain cancer in adults, tend to develop in different regions of the brain. This finding provides an explanation for how the same cancer-causing mutation can give rise to…
How Pancreatic Cancer Defies Treatment
January 19, 2023
UC San Diego researchers describe how pancreatic cancer stem cells leverage a protein in a family of proteins that normally suppress tumors to instead do the opposite, boosting their resistance to conventional treatments and spurring growth.
Researchers Find a New Way to Identify and Target Malignant Aging in Leukemia
August 26, 2016
…identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.
UC San Diego Researchers Launch Combination Drug Trial to Eradicate B-Cell Malignancies
March 9, 2018
…grant from the state’s stem cell agency, researchers at University of California San Diego School of Medicine, in collaboration with local biotechnology company Oncternal Therapeutics, have launched a phase Ib/II clinical trial to evaluate the combined effectiveness of a standard of care drug with a novel monoclonal antibody that target…
In Effort to Treat Rare Blinding Disease, Researchers Turn Stem Cells into Blood Vessels
February 14, 2018
Researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health have discovered that a chemical compound that activates ATF6, a gene associated with an inherited vision impairment, also converts patient-derived stem cells into blood vessels.
In First Moments of Infection, a Division and a Decision
March 4, 2014
…the destiny of single cells, researchers at the University of California, San Diego School of Medicine describe for the first time the earliest stages of fate determination among white blood cells called T lymphocytes, providing new insights that may help drug developers create more effective, longer-lasting vaccines against microbial pathogens…
