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Your search for “DNA Repair” returned 57 results

Supercomputer Simulations Show How DNA Prepares Itself for Repair

June 25, 2020

Researchers from Harvard University and the University of Texas Medical Branch at Galveston recently used the Comet supercomputer at the San Diego Supercomputer Center at the University of California San Diego to uncover the novel ways in which DNA prepares itself for repair.

How Cells Remodel After UV Radiation

December 19, 2013

Researchers at the University of California, San Diego School of Medicine, with colleagues in The Netherlands and United Kingdom, have produced the first map detailing the network of genetic interactions underlying the cellular response to ultraviolet (UV) radiation.

DNA Mismatch Repair Happens Only During A Brief Window of Opportunity

December 22, 2011

In eukaryotes – the group of organisms that include humans – a key to survival is the ability of certain proteins to quickly and accurately repair genetic errors that occur when DNA is replicated to make new cells.

Study Reveals How Enzyme Detects Ultraviolet Light Damage

August 22, 2018

In a paper published this week in the journal PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Spain and Finland, describe for the first time how one type of RNA polymerase gets stalled by DNA lesions caused by exposure to ultraviolet (UV) light.

“Soft” CRISPR May Offer a New Fix for Genetic Defects

July 1, 2022

Scientists have developed a CRISPR-based technology that could offer a safer approach to correcting genetic defects. The new “soft” CRISPR system makes use of natural DNA repair machinery, providing a foundation for novel gene therapy strategies with the potential to cure genetic diseases.

Biologists Discover Source for Boosting Tumor Cell Drug Sensitivity

October 29, 2018

…to the potency of DNA-damaging agents, the most widely used group of cancer drugs. In a new study, they describe how a human gene known as Schlafen 11 controls the sensitivity of tumor cells to DDAs. Their research may pave the way to new strategies to overcome chemotherapeutic drug resistance.

For First Time, Scientists Use CRISPR-Cas9 to Target RNA in Live Cells

March 17, 2016

…Medicine have now achieved this by applying the popular DNA-editing technique CRISPR-Cas9 to RNA. The study is published March 17 in Cell.

Netflix-Style Algorithm Builds Blueprint of Cancer Genomes

June 15, 2022

The science behind predicting your viewing habits on Netflix could one day be used to guide doctors in managing some of the hardest-to-treat cancers, shows a study led by the University of California San Diego and University College London.

New Version of DNA Editing System Corrects Underlying Defects in RNA-based Diseases

August 10, 2017

…be used to manipulate DNA. In 2016, University of California San Diego School of Medicine researchers repurposed the technique to track RNA in live cells in a method called RNA-targeting Cas9. In a study published August 10 in Cell, the team took RCas9 a step further: they corrected molecular mistakes…

Breaking Bad: How Shattered Chromosomes Make Cancer Cells Drug-Resistant

December 23, 2020

UC San Diego and Ludwig Cancer Research scientists describe how a phenomenon known as “chromothripsis” breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth.

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