September 28, 2017
September 28, 2017 —
A team of researchers has engineered smart protein molecules that can reprogram white blood cells to ignore a self-defense signaling mechanism that cancer cells use to survive and spread in the body. Researchers say the advance could lead to a new method of re-engineering immune cells to fight cancer and infectious diseases. The team successfully tested this method in a live cell culture system.
September 27, 2017
September 27, 2017 —
Cancers driven by mutations in the KRAS gene are among the most deadly. For decades, researchers have tried unsuccessfully to directly target mutant KRAS proteins as a means to treat tumors. Instead of targeting mutant KRAS itself, researchers at University of California San Diego School of Medicine are now looking for other genes or molecules that, when inhibited, kill cancer cells only when KRAS is also mutated.
September 22, 2017
September 22, 2017 —
More than 100 physicians from UC San Diego Health were named “Top Docs” in the annual San Diego Magazine “Physicians of Exceptional Excellence” annual survey. These physicians represent 45 diverse specialties, from infectious disease, surgery and oncology to obstetrics, cardiology and emergency medicine.
September 21, 2017
September 21, 2017 —
Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes. But the mechanism by which this occurs has remained cloaked, until now. In a paper, University of California San Diego School of Medicine researchers identified exosomes — extremely small vesicles or sacs secreted from most cell types — as the missing link.
September 21, 2017
September 21, 2017 —
Checkpoint inhibitor-based immunotherapy has been shown to be very effective in recurrent and metastatic head and neck cancer but only in a minority of patients. University of California San Diego School of Medicine researchers may have found a way to double down on immunotherapy’s effectiveness.
September 20, 2017
September 20, 2017 —
Researchers at University of San Diego School of Medicine have developed a new tool called the San Diego Wisdom Scale (SD-WISE) to assess an individual’s level of wisdom, based upon a conceptualization of wisdom as a trait with a neurobiological as well as psychosocial basis.
September 19, 2017
September 19, 2017 —
It is estimated that up to 75 percent of breast cancer survivors experience problems with cognitive difficulties following treatments, perhaps lasting years. Currently, few science-based options are available to help. University of California San Diego School of Medicine researchers report in a pilot study of 87 female breast cancer survivors that an increase in physical activity more than doubled the women’s post-treatment mental processing speed.
September 15, 2017
September 15, 2017 —
A team of researchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System analyzed published longitudinal studies of mortality in schizophrenia that met their strict research criteria and found that the mean standardized mortality ratio – a measure of the mortality rate in schizophrenia – has increased 37 percent from pre-1970s studies to post-1970s studies.
September 13, 2017
September 13, 2017 —
In a new study, published this month in Cancer Discovery, University of California San Diego School of Medicine researchers report that approximately half of lung and pancreatic cancers that originate with a KRAS mutation become addicted to the gene as they progress.
September 12, 2017
September 12, 2017 —
A team of researchers led by a bioinformatician at the University of California San Diego has developed a method to help determine whether certain hard-to-study mutations in the human genome, called short tandem repeats or microsatellites, are likely to be involved in harmful conditions. The team, which also includes scientists from the New York Genome Center, Harvard University, and the Massachusetts Institute of Technology, details their findings in the Sept. 11 issue of Nature Genetics.
