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Your search for “genetics” returned 1148 results

First-in-Human Clinical Trial to Assess Gene Therapy for Alzheimer’s Disease

UC San Diego researchers have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer’s disease or Mild Cognitive Impairment, a condition that often precedes full-blown dementia.

Gene Therapy in Alzheimer’s Disease Mouse Model Preserves Learning and Memory

Researchers at UC San Diego have used gene therapy to prevent learning and memory loss in a mouse model of Alzheimer’s disease, a key step toward eventually testing the approach in humans with the neurodegenerative disease.

Controlling Cholesterol in Microglia Alleviates Chronic Pain, Opioid-Free

Using a mouse model, researchers discover pivotal role of cholesterol in chronic pain often caused by chemotherapy, and propose novel therapy.

Superficial Relationship: Enzymes Protect the Skin by Ignoring Microbes and Viruses

UC San Diego School of Medicine researchers identify how the body regulates and prevents constant skin inflammation.

UC San Diego Health Begins Treating Multiple Myeloma with CAR T-cell Therapy

As the first designated medical center in San Diego certified to offer this type of immunotherapy, UC San Diego Health will begin treating patients this month.

Potential Drug Target for Difficult-To-Treat Breast Cancer: RNA-Binding Proteins

UC San Diego studies using human cell lines and tumors grown in mice provide early evidence that inhibiting RNA-binding proteins, a previously overlooked family of molecules, might provide a new approach for treating some cancers.

Artificial Intelligence Could Be New Blueprint for Precision Drug Discovery

Researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval.

Ultrasound Remotely Triggers Immune Cells to Attack Tumors in Mice Without Toxic Side Effects

A new cancer immunotherapy pairs ultrasound with cancer-killing immune cells to destroy malignant tumors while sparing normal tissue. The approach could make chimeric antigen receptor (CAR) T-cell therapy safer and effective at treating solid tumors.

A Target for Potential Cancer Drugs May, In Fact, Worsen Disease

Researchers reveal a previously unrealized complexity in cancer development, one that raises concerns and caution about targeting an enzyme popular in oncological treatments.

State Stem Cell Agency Awards $4M for Blood Cancer Immunotherapy at UC San Diego

The California Institute for Regenerative Medicine (CIRM) approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T-cell therapy from the laboratory into the clinic.