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Your search for “gene therapy” returned 715 results

Finding Keys to Glioblastoma Therapeutic Resistance

August 25, 2014

…a deadly brain cancer – are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature. These findings have been published online as a priority report in the journal Oncotarget.

Molecular Tumor Board Helps in Advanced Cancer Cases

May 5, 2014

With accelerating development of personalized cancer treatments matched to a patient’s DNA sequencing, proponents say frontline physicians increasingly need help to maneuver through the complex genomic landscape to find the most effective, individualized therapy.

Gene Mutation “Hotspots” Linked to Better Breast Cancer Outcomes

June 30, 2016

Using a database of human tumor genomic data, researchers at the University of California San Diego, School of Medicine and Moores Cancer Center discovered that mutation hotspots known as kataegis are a positive marker in breast cancer — patients with kataegis have less invasive tumors and better prognoses. The study,…

UC San Diego Health Joins National Clinical Trial on Hemophilia B Gene Therapy

March 22, 2016

The Hemophilia and Thrombosis Treatment Center at UC San Diego Health has joined a nationwide clinical trial testing a potential gene therapy that may one day provide a better and long-lasting treatment for people with hemophilia B.

Using CRISPR to Reverse Retinitis Pigmentosa and Restore Visual Function

April 21, 2017

Using the gene-editing tool CRISPR/Cas9, researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China, have reprogrammed mutated rod photoreceptors to become functioning cone photoreceptors, reversing cellular degeneration and restoring visual function in two mouse models of…

In Effort to Treat Rare Blinding Disease, Researchers Turn Stem Cells into Blood Vessels

February 14, 2018

Researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health have discovered that a chemical compound that activates ATF6, a gene associated with an inherited vision impairment, also converts patient-derived stem cells into blood vessels.

Breaking Bad: How Shattered Chromosomes Make Cancer Cells Drug-Resistant

December 23, 2020

UC San Diego and Ludwig Cancer Research scientists describe how a phenomenon known as “chromothripsis” breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth.

Scientists Race to Outpace Lethal Bacterial Infections

May 30, 2018

…ground by demonstrating the first example of an effective gene therapy for deadly bacterial infections.

Discovery of Wound-Healing Genes in Flies Could Mitigate Human Skin Ailments

April 24, 2013

Biologists at UC San Diego have identified eight genes never before suspected to play a role in wound healing that are called into action near the areas where wounds occur.

Gene Mutations Cause Massive Brain Asymmetry

June 25, 2012

…say de novo somatic mutations in a trio of genes that help regulate cell size and proliferation are likely culprits for causing hemimegalencephaly, though perhaps not the only ones.

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