Brain Cancer Cells Hide While Drugs Seek
December 5, 2013
…of Medicine, has found that brain cancer cells resist therapy by dialing down the gene mutation targeted by drugs, then re-amplify that growth-promoting mutation after therapy has stopped.
Your search for “gene therapy” returned 741 results
Gene Editing Technique Helps Find Cancer’s Weak Spots
March 20, 2017
Genetic mutations that cause cancer also weaken cancer cells, allowing researchers to develop drugs that will selectively kill them. This is called “synthetic lethality” because the drug is only lethal to mutated (synthetic) cells. Researchers at UC San Diego School of Medicine and Jacobs School of Engineering developed a method…
New Personalized Immunotherapy Trial Launched Despite COVID-19 Pandemic
December 10, 2020
…undergo an investigational cell therapy that uses a patient’s own, lab-grown tumor infiltrating lymphocytes (immune cells) to destroy his cancer. New Personalized Immunotherapy Trial Launched Despite COVID-19 Pandemic First patient to receive individualized TIL therapy undergoes treatment at Moores Cancer Center Since 2016, Bernard Thurman has undergone traditional treatments, experimental…
Genetic Mutations of Appendix Cancer Identified, May Impact Treatment
August 8, 2018
…Cancer Center researchers, in collaboration with Foundation Medicine, performed genetic profiling on 703 appendiceal tumors — the largest such study of this disease to date — to compare mutations present in both cancer types.
Researchers Find Fertility Genes Required for Sperm Stem Cells
September 27, 2016
…of transcription factors — regulatory proteins that activate some genes and inactivate others — drive the development of stem cells in the testes in mice. The investigators also linked RHOX gene mutations to male infertility in humans.
Enhancer RNAs Alter Gene Expression
June 3, 2013
…or “eRNAs” could provide a new way to alter gene expression in living cells, perhaps affecting the development or pathology of many diseases.
Mutant Gene Found to Fuel Cancer-Promoting Effects of Inflammation
October 23, 2017
…mechanism linking a human gene’s function to chronic inflammation and cancer. Through large-scale genomic analyses, they discovered that “mutant p53” amplifies the impact of inflammation, leading to increases in cancer. Thus, rather than fighting tumor growth, mutant forms of p53 appear to be tapping into the body’s immune response system…
Weak Brain Circadian Rhythms Cause Depression-Like Behavior in Mice
May 2, 2016
When the master pacemaker that normally synchronizes circadian rhythms in the brain is disrupted, that disruption causes helplessness, behavioral despair, and anxiety-like behavior in mice, say scientists at the University of California San Diego.
New Genetic Analysis Tool Tracks Risks Tied to CRISPR Edits
March 26, 2024
While CRISPR has shown immense promise as a next-generation therapeutic tool, the gene editing technology’s edits are still imperfect. Researchers have developed a new genetic system to test and analyze CRISPR-based DNA repair and related risks from unintended but harmful “bystander” edits.
UC San Diego Health Researchers Join Pancreatic Cancer “Dream Team”
November 9, 2015
In an effort to advance research on one of the deadliest forms of cancer, University of California, San Diego School of Medicine researchers Andrew Lowy, MD, and Tannishtha Reya, PhD, have been recruited for their expertise in preclinical modeling, clinical trials and stem cell biology to join a “dream team”…
