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Your search for “gene therapy” returned 728 results

New Personalized Immunotherapy Trial Launched Despite COVID-19 Pandemic

December 10, 2020

…undergo an investigational cell therapy that uses a patient’s own, lab-grown tumor infiltrating lymphocytes (immune cells) to destroy his cancer. New Personalized Immunotherapy Trial Launched Despite COVID-19 Pandemic First patient to receive individualized TIL therapy undergoes treatment at Moores Cancer Center Since 2016, Bernard Thurman has undergone traditional treatments, experimental…

Genetic Mutations of Appendix Cancer Identified, May Impact Treatment

August 8, 2018

…Cancer Center researchers, in collaboration with Foundation Medicine, performed genetic profiling on 703 appendiceal tumors — the largest such study of this disease to date — to compare mutations present in both cancer types.

Researchers Find Fertility Genes Required for Sperm Stem Cells

September 27, 2016

…of transcription factors — regulatory proteins that activate some genes and inactivate others — drive the development of stem cells in the testes in mice. The investigators also linked RHOX gene mutations to male infertility in humans.

Mutant Gene Found to Fuel Cancer-Promoting Effects of Inflammation

October 23, 2017

…mechanism linking a human gene’s function to chronic inflammation and cancer. Through large-scale genomic analyses, they discovered that “mutant p53” amplifies the impact of inflammation, leading to increases in cancer. Thus, rather than fighting tumor growth, mutant forms of p53 appear to be tapping into the body’s immune response system…

Enhancer RNAs Alter Gene Expression

June 3, 2013

…or “eRNAs” could provide a new way to alter gene expression in living cells, perhaps affecting the development or pathology of many diseases.

Weak Brain Circadian Rhythms Cause Depression-Like Behavior in Mice

May 2, 2016

When the master pacemaker that normally synchronizes circadian rhythms in the brain is disrupted, that disruption causes helplessness, behavioral despair, and anxiety-like behavior in mice, say scientists at the University of California San Diego.

New Genetic Analysis Tool Tracks Risks Tied to CRISPR Edits

March 26, 2024

While CRISPR has shown immense promise as a next-generation therapeutic tool, the gene editing technology’s edits are still imperfect. Researchers have developed a new genetic system to test and analyze CRISPR-based DNA repair and related risks from unintended but harmful “bystander” edits.

UC San Diego Health Researchers Join Pancreatic Cancer “Dream Team”

November 9, 2015

In an effort to advance research on one of the deadliest forms of cancer, University of California, San Diego School of Medicine researchers Andrew Lowy, MD, and Tannishtha Reya, PhD, have been recruited for their expertise in preclinical modeling, clinical trials and stem cell biology to join a “dream team”…

Using CRISPR to Reverse Retinitis Pigmentosa and Restore Visual Function

April 21, 2017

Using the gene-editing tool CRISPR/Cas9, researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China, have reprogrammed mutated rod photoreceptors to become functioning cone photoreceptors, reversing cellular degeneration and restoring visual function in two mouse models of…

“Soft” CRISPR May Offer a New Fix for Genetic Defects

July 1, 2022

Scientists have developed a CRISPR-based technology that could offer a safer approach to correcting genetic defects. The new “soft” CRISPR system makes use of natural DNA repair machinery, providing a foundation for novel gene therapy strategies with the potential to cure genetic diseases.

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