Computational Strategy Helps to Map Human Epigenome
February 18, 2015
…those differences, a body of information they call the epigenome.
Your search for “epigenomics” returned 32 results
New Insights into 3D Genome Organization and Genetic Variability
February 18, 2015
…a cell or organism, epigenomics is the study of all the genomic add-ons and changes that influence gene expression but aren’t encoded in the DNA sequence. A variety of new epigenomic information is now available in a collection of studies published Feb. 19 in Nature by the National Institutes of…
Mapping the Pancreatic Islets
October 24, 2018
The mechanism leading to development of type 1 diabetes remains a mystery, hampering the ability to find new ways to prevent, treat or even cure this condition. With a new $3.3 million grant, University of California School of Medicine researchers hope to create a high resolution reference map of pancreatic…
Program Predicts Placement of Chemical Tags that Control Gene Activity
September 22, 2014
Biochemists working at the University of California, San Diego, have developed a program that predicts the placement of chemical marks that control the activity of genes based on sequences of DNA. They describe their analysis and report results from its application to human embryonic cells in a paper published in…
$6M NIH Grant Launches UC San Diego Consortium to Study Insulin-Producing Cells
September 9, 2021
UC San Diego School of Medicine researchers will receive $6.4 million in National Institutes of Health grant funding to study how external signals and genetic variations influence the behavior of one cell type in particular: insulin-producing beta cells in the pancreas.
Mapping the Mouse Brain, and by Extension, the Human Brain Too
October 6, 2021
In a special issue of Nature, UC San Diego researchers further refine the organization of cells within key regions of the mouse brain and the organization of transcriptomic, epigenomic and regulatory factors that provide these brain cells with function and purpose.
Genetic Tools Help Identify a Cellular Culprit for Type 1 Diabetes
May 19, 2021
By mapping its genetic underpinnings, researchers at University of California San Diego School of Medicine have identified a predictive causal role for specific cell types in type 1 diabetes, a condition that affects more than 1.6 million Americans.
Joint Resolution: A Link Between Huntington’s Disease and Rheumatoid Arthritis
May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common autoimmune disease that affects more than 1.3 million Americans.
In Epigenomics, Location is Everything
January 3, 2013
In a novel use of gene knockout technology, researchers at the University of California, San Diego School of Medicine tested the same gene inserted into 90 different locations in a yeast chromosome –and discovered that while the inserted gene never altered its surrounding chromatin landscape, differences in that immediate landscape…
Illuminating Dark Matter in Human DNA
November 12, 2021
UC San Diego researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.
