June 8, 2021
…different approach than growing organoids for drug screening, explained Chen. “With organoids, you’re mixing different types of cells and letting them to self-organize to form a 3D structure that is not well controlled and can vary from one experiment to another. Thus, they are not reproducible for the same property,…
January 27, 2022
…screening method on brain organoids. “We want to take this a step further to screen drugs on more realistic tissues, not just neurons in a dish,” said Subramaniam. The team will also work on developing new Alzheimer’s drug candidates and screening them with their method. Paper: “Endotype reversal as a…
July 20, 2022
…elements in human lung organoids, in a hamster model of COVID-19, and could confirm their presence in the lungs of deceased individuals with COVID-19. Key elements were also reversed in the hamsters using anti-SARS-COV-2 therapeutics. A deeper analysis pinpointed endoplasmic reticulum stress as the shared early trigger of both post-COVID…
January 16, 2020
…cells. 3D human brain organoids. Left: normal, uninfected. Center: infected with Zika virus. Right: infected with Zika virus and treated with cilengitide, which protects the cells from destruction by the virus. Their study, published in Cell Reports, uncovered 92 specific human brain cancer stem cell genes that Zika virus requires…
September 22, 2022
Genetic Variation Explains Racial Disparity in Esophageal Cancer Cases
January 30, 2019
…development of human brain organoids derived from reprogrammed cells from ASD individuals.” Epigenetics refers to changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. Epigenetic control of chromatin structure — how DNA is efficiently packaged within a cell’s nucleus — mediates many…
June 2, 2016
…cells and in cerebral organoids – miniature, 3D brains grown in vitro. Most telling: Infected pregnant mice gave birth to pups displaying not just undersized heads and brains, but overall stunted growth. “The data in mice also suggest that microcephaly is only the tip of the iceberg,” said Muotri. “The…
April 26, 2018
…of participants’ neurons and organoids — simple but organized, functional, three-dimensional cell assemblies sometimes called “mini-brains.” Muotri and colleagues created the first human cellular model of autism, which can be used as a tool for testing, diagnosis and drug screening, in 2010. Second, Gabriel A. Silva, PhD, professor of bioengineering…
April 26, 2018
…of participants’ neurons and organoids—simple but organized, functional, three-dimensional cell assemblies sometimes called “mini-brains.” Muotri and colleagues created the first human cellular model of autism, which can be used as a tool for testing, diagnosis and drug screening, in 2010. Second, Gabriel A. Silva, a professor of bioengineering and neurosciences…
September 6, 2022
…stem cell-derived human brain organoids to the International Space Station (ISS) orbiting almost 250 miles above Earth to study how these masses of cells organize into the beginnings of a functional brain in microgravity. The first-ever project of its type was dedicated to Sanford, a longtime supporter of Muotri’s work…
