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Your search for “organoids” returned 40 results

Inflamed Support Cells Appear to Contribute to Some Kinds of Autism

October 18, 2017

…cells were grown into organoids, essentially mini-brains in a dish. Though genetically distinct, all three children displayed stereotypical ASD behaviors, such as lack of verbal skills or social interaction. When researchers examined the developed organoids in microscopic detail, they noted that the neurons had fewer synapses (connections to other neurons)…

How a Single Gene Alteration May Have Separated Modern Humans from Predecessors

February 11, 2021

…used to build brain organoids — “mini brains” in a laboratory dish. Muotri and colleagues have pioneered the use of stem cells to compare humans to other primates, such as chimpanzees and bonobos, but until now a comparison with extinct species was not thought possible. In a study published February…

Gene Therapy Reverses Effects of Autism-Linked Mutation in Brain Organoids

May 2, 2022

…Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. Using gene therapy tools to recover the gene’s function effectively rescued neural structure and function. Several neurological and neuropsychiatric diseases, including autism spectrum disorders (ASD) and schizophrenia have been…

Organoids Reveal Similarities Between Myotonic Dystrophy Type 1 and Rett Syndrome

June 29, 2022

…Medicine used three-dimensional brain organoids — self-organized tissue grown from stem cells that mimics neurological functions — to discover fundamental similarities between DM1 and RS, and perhaps therapeutic opportunities. "We turned to 3D brain organoids that simulate the developing human cortex to study the effects of the CTG repeat expansion…

Machine Learning Algorithm Can’t Distinguish These Lab Mini-Brains from Preemie Babies

August 29, 2019

Brain organoids — also called mini-brains — are 3D cellular models that represent aspects of the human brain in the laboratory. Brain organoids help researchers track human development, unravel the molecular events that lead to disease and test new treatments. They aren’t prefect replicas, of course. Brain organoids do not…

2019: A Space Organoid

July 8, 2019

…stem cell-derived human brain organoids to the International Space Station (ISS) orbiting almost 250 miles above Earth, where researchers will document how these masses of cells organize into the beginnings of a functional brain. The first-ever project of its type is dedicated to T. Denny Sanford, a longtime advocate of…

Creating an Engineering Senior Design Project….at Home

July 2, 2020

…rocket launch on brain organoids being sent to space. One team of students, sponsored by the Arthur C. Clarke Center for Human Imagination and Space Tango, was tasked with designing a way for researchers to study the effects of a rocket launch on brain organoids being sent to the International…

UC San Diego Receives $9 Million in Grants to Pinpoint Cellular Cause of Type 1 Diabetes

August 13, 2019

…cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes aimed at identifying the elusive cellular actions leading to disease onset. “We are using technology that, for the first time, allows us to create human conditions that mimic type 1…

Brazilian Zika Virus Strain Causes Birth Defects in Experimental Models

May 11, 2016

…cells and in cerebral organoids – miniature brains grown in vitro. “Rising infection rates of Zika virus in places like Brazil, with a corresponding increase in cases of microcephaly, have powerfully suggested an association, but until now hard evidence has been lacking,” said Muotri. “Our findings provide direct experimental proof…

Study: E-Cigarettes Trigger Inflammation in the Gut

January 7, 2021

…produce the 3D gut organoids, the researchers collected stem cells from patients’ biopsies during colonoscopies and grew them in vitro. The stem cells differentiated into the four different cell types that make up the gut lining. The team then exposed the organoids to e-cigarette liquid vapor, mimicking the frequency of…

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