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Your search for “organoids” returned 39 results

Brain Organoids Reveal in Detail the Harms of Prenatal Alcohol Exposure

November 18, 2022

Brain Organoids Reveal in Detail the Harms of Prenatal Alcohol Exposure

Organoids Reveal How SARS-CoV-2 Damages Brain Cells — and a Potential Treatment

November 3, 2022

Organoids Reveal How SARS-CoV-2 Damages Brain Cells — and a Potential Treatment

Human Lung and Brain Organoids Respond Differently to SARS-CoV-2 Infection in Lab Tests

February 24, 2021

…are using stem cell-derived organoids — small balls of human cells that look and act like mini-organs in a laboratory dish — to study how the virus interacts with various organ systems and to develop therapies to block infection. UC San Diego School of Medicine researchers found approximately 10-fold higher…

Brain Organoids Mimic Head Size Changes Associated with Type of Autism

August 25, 2021

…researchers are using brain organoids — tiny, 3D cellular models generated in the lab from people with 16p11.2 variations. The organoids, described in a paper publishing August 25, 2021 in Molecular Psychiatry, mimicked the differences in brain size seen in people. They also revealed new information about the molecular mechanisms…

Building a Better Brain-in-a-Dish, Faster and Cheaper

September 6, 2018

…to create human cortical organoids directly from primary cells. Experimental studies of developing human brain function are limited. Research involving live embryonic subjects is constrained by ethical concerns and the fragile nature of the brain itself. Animal models only partially mimic or recapitulate human biology and cognitive function. Single cell…

Zika Virus May Cause Microcephaly by Hijacking Human Immune Molecule

May 6, 2016

…and survival, causing the organoids to shrink — an effect reminiscent of microcephaly. “We all have an innate immune system that evolved specifically to fight off viruses, but here the virus turns that very same defense mechanism against us,” said senior author Tariq Rana, PhD, professor of pediatrics at UC…

Human Mini-Lungs Grown in Lab Dishes are Closest Yet to Real Thing

August 31, 2021

…also known as lung organoids that represent all cell types. They also report that SARS-CoV-2 infection of the lung organoids replicates real-world patient lung infections, and reveals the specialized roles various cell types play in infected lungs. “This human disease model will now allow us to test drug efficacy and…

Two UC San Diego Researchers Receive NIH High-Risk, High-Reward Awards

October 6, 2020

…on creating electronic brain organoids, or “e-Organoids.” These are essentially brain tissues—formed by self-assembled, 3D structures generated from human stem cells—embedded with hundreds of individually controllable sensors. Brain organoids are of great interest to researchers because they mimic the embryonic human brain, and thus potentially offer unprecedented opportunities for studying…

Lab-Grown Human Brain Organoids Mimic an Autism Spectrum Disorder, Help Test Treatments

December 8, 2020

…used stem cell-derived brain organoids — also called “mini-brains” — that lack the functional MECP2 gene to better study the disease. In a study publishing December 8, 2020 in EMBO Molecular Medicine, the team identified two drug candidates that counteract the deficiencies caused by lack of the MECP2 gene. These…

Inflamed Support Cells Appear to Contribute to Some Kinds of Autism

October 18, 2017

…cells were grown into organoids, essentially mini-brains in a dish. Though genetically distinct, all three children displayed stereotypical ASD behaviors, such as lack of verbal skills or social interaction. When researchers examined the developed organoids in microscopic detail, they noted that the neurons had fewer synapses (connections to other neurons)…

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