‘Leaky’ Activity of Mutated Enzyme Underlies Neurodegenerative Disease
October 3, 2022
UC San Diego study finds enhanced PKCγ activity drives spinocerebellar ataxia type 14; suggests inhibiting the enzyme may have therapeutic potential
Your search for “neurodegenerative disease” returned 152 results
Albert La Spada Receives Harrington Scholar Award to Combat Neurodegenerative Disease
September 21, 2015
Albert La Spada, MD, PhD, professor of pediatrics, cellular and molecular medicine and neurosciences at University of California, San Diego School of Medicine, has received a 2015 Harrington Scholar award to advance his work on a therapy for Spinocerebellar ataxia type 7 (SCA7), a rare but devastating neurological disorder that…
Experimental Drug Blocks Toxic Ion Flow Linked to Alzheimer’s Disease
December 5, 2017
…function and memory in a mouse model of Alzheimer’s disease. The molecule, called anle138b, works by stopping toxic ion flow in the brain that is known to trigger nerve cell death. Scientists envision that this drug could be used to treat Alzheimer’s and other neurodegenerative diseases such as Parkinson’s and…
Junior Seau Foundation Supports Brain Injury Studies and Education at UC San Diego
December 15, 2016
…was subsequently diagnosed with chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repeated blows to the head.
Color-Coded Markers May Help Doctors Diagnose Neural Diseases Through the Eyes
August 15, 2012
Sticky plaques of proteins called amyloids mark several different, though related degenerative brain diseases including Alzheimer’s, Parkinson’s and Creutzfeld-Jacobs. The symptoms of these disorders overlap and methods to diagnose and monitor them are not very advanced.
Don Cleveland Wins a Trifecta of Recognition
January 31, 2023
In the span of just a few weeks, Don Cleveland, a leading researcher in the study of neurodegenerative diseases like ALS and Alzheimer’s, has received three major awards.
Target Identified For Rare Inherited Neurological Disease In Men
August 10, 2014
Researchers at University of California, San Diego School of Medicine have identified the mechanism by which a rare, inherited neurodegenerative disease causes often crippling muscle weakness in men, in addition to reduced fertility.
Proposed Drug May Reverse Huntington’s Disease Symptoms
June 20, 2012
With a single drug treatment, researchers at the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine can silence the mutated gene responsible for Huntington’s disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.
Researchers Discover Clue to How to Protect Neurons and Encourage Their Growth
December 14, 2020
Researchers have identified a family of enzymes whose inhibition both protects neurons and encourages their growth, a pathway to potential new treatments for neurodegenerative diseases from Alzheimer’s to glaucoma.
Corrected Protein Structure Reveals Drug Targets for Cancer, Neurodegenerative Diseases
August 13, 2015
…or death. When it goes awry, a number of diseases may result. In a study, researchers at University of California, San Diego School of Medicine reveal a more accurate structure of PKC, providing new targets for fine-tuning the enzyme’s activity as needed to improve human health.
