December 17, 2019
In a UC San Diego study, rats with spinal cord injuries experienced a three-fold increase in motor activity when treated with neural progenitor cells that had been pre-conditioned with a modified form of tPA, a drug commonly used to treat non-hemorrhagic stroke.
March 31, 2016
Researchers at University of California, San Diego School of Medicine and University of British Columbia (UBC) have determined that, in mice, age diminishes ability to regenerate axons, the brain’s communication wires in the spinal cord. The study is published March 31 in Cell Reports.
May 9, 2022
An international team of researchers, led by scientists at UC San Diego, report that a gene therapy that inhibits targeted nerve cell signaling effectively reduced neuropathic pain with no detectable side effects in mice with spinal cord or peripheral nerve injuries.
April 15, 2020
When adult brain cells are injured, they revert to an embryonic state, say researchers at UC San Diego School of Medicine. In their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.
August 28, 2017
…report that human neural stem cells (NSCs) grafted into spinal cord injuries in laboratory rats displayed continued growth and maturity, with functional recovery beginning one year after grafting.
May 25, 2012
…Medicine (CIRM) to conduct stem cell-based research into regenerating spinal cord injuries, repairing gene mutations that cause amyotrophic lateral sclerosis and finding new drugs to treat heart failure and Alzheimer’s disease.
March 28, 2016
Writing in Nature Medicine, researchers at University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System, with colleagues in Japan and Wisconsin, report that they have successfully directed stem cell-derived neurons to regenerate lost tissue in damaged corticospinal tracts of rats, resulting in functional benefit.
March 8, 2018
…Chair in Traumatic Brain Injury at the University of California San Diego is Yishi Jin, Professor and Chair of the Section of Neurobiology in the Division of Biological Sciences. Jin’s research focuses on molecular genetic mechanisms underlying the development of the nervous system, and regeneration of wounded nervous systems, with…
February 27, 2013
After four years of confinement to a wheelchair, Rick Constantine, 58, is now walking again after undergoing an unconventional surgery at University of California, San Diego Heath System to restore the use of his leg. Neurosurgeon Justin Brown, MD, performed the novel 3-hour procedure.
February 26, 2018
…grafted human neural progenitor cells into rhesus monkeys with spinal cord injuries. The grafts not only survived, but grew hundreds of thousands of human axons and synapses, resulting in improved forelimb function in the monkeys.
