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Your search for “Single-cell atlas” returned 13 results

Single-Cell Atlas of the Human Kidney Provides New Resources To Study Kidney Disease

July 19, 2023

What causes certain individuals who experience a sudden decline in kidney function to develop kidney disease while others recover? A new study co-led by UC San Diego bioengineers could provide insight—at the single-cell level—into the underlying factors contributing to these divergent outcomes.

In Mice, Alcohol Dependence Results in Brain-Wide Remodeling of Functional Architecture

January 14, 2020

Using novel imaging technologies, researchers produce first whole-brain atlas at single-cell resolution, revealing how alcohol addiction and abstinence remodel neural physiology and function in mice.

Bioengineers Awarded $14M from NIH to Build Digital Maps of Brain, Other Organs at Single-Cell Level

November 2, 2018

…the National Institutes of Health to build 3D, digital single-cell maps of the human brain and organs in the respiratory and urinary systems. The work aims to provide a deeper understanding of the functions and malfunctions of organs in the human body at the level of individual cells.

Illuminating Dark Matter in Human DNA

November 12, 2021

UC San Diego researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.

Researchers Map Lung Development After Birth Into Late Childhood for the First Time

April 12, 2022

How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? UC San Diego researchers developed a single-cell atlas of postnatal lung development that could help answer these questions.

Mapping the Pancreatic Islets

October 24, 2018

The mechanism leading to development of type 1 diabetes remains a mystery, hampering the ability to find new ways to prevent, treat or even cure this condition. With a new $3.3 million grant, University of California School of Medicine researchers hope to create a high resolution reference map of pancreatic…

UC San Diego, Salk and Others Seek to Map the Human Brain Over a Lifetime

September 22, 2022

With a $126 million grant from the National Institutes of Health, a multi-institution team of researchers at UC San Diego, Salk Institute and elsewhere has launched a new Center for Multiomic Human Brain Cell Atlas to describe human brain cells in unprecedented detail over a lifetime.

Updated Brain Cell Map Connects Various Brain Diseases to Specific Cell Types

December 11, 2017

Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer’s, Parkinson’s, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered…

Cellular Atlas of Amygdala Reveals New Treatment Target for Cocaine Addiction

October 5, 2023

Researchers at University of California San Diego School of Medicine have used single-cell sequencing to identify a potential new treatment for cocaine addiction and shed new light on the molecular underpinnings of addiction.

Mapping the Mouse Brain, and by Extension, the Human Brain Too

October 6, 2021

In a special issue of Nature, UC San Diego researchers further refine the organization of cells within key regions of the mouse brain and the organization of transcriptomic, epigenomic and regulatory factors that provide these brain cells with function and purpose.

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