July 19, 2023
What causes certain individuals who experience a sudden decline in kidney function to develop kidney disease while others recover? A new study co-led by UC San Diego bioengineers could provide insight—at the single-cell level—into the underlying factors contributing to these divergent outcomes.
November 2, 2018
…the National Institutes of Health to build 3D, digital single-cell maps of the human brain and organs in the respiratory and urinary systems. The work aims to provide a deeper understanding of the functions and malfunctions of organs in the human body at the level of individual cells.
April 12, 2022
How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? UC San Diego researchers developed a single-cell atlas of postnatal lung development that could help answer these questions.
November 12, 2021
UC San Diego researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.
October 24, 2018
The mechanism leading to development of type 1 diabetes remains a mystery, hampering the ability to find new ways to prevent, treat or even cure this condition. With a new $3.3 million grant, University of California School of Medicine researchers hope to create a high resolution reference map of pancreatic…
December 11, 2017
Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer’s, Parkinson’s, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered…
January 14, 2020
Using novel imaging technologies, researchers produce first whole-brain atlas at single-cell resolution, revealing how alcohol addiction and abstinence remodel neural physiology and function in mice.
May 23, 2024
UC San Diego biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new “gene atlas” with 4D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
September 22, 2022
With a $126 million grant from the National Institutes of Health, a multi-institution team of researchers at UC San Diego, Salk Institute and elsewhere has launched a new Center for Multiomic Human Brain Cell Atlas to describe human brain cells in unprecedented detail over a lifetime.
October 6, 2021
In a special issue of Nature, UC San Diego researchers further refine the organization of cells within key regions of the mouse brain and the organization of transcriptomic, epigenomic and regulatory factors that provide these brain cells with function and purpose.
