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Your search for “Pathology” returned 343 results

New 3D Imaging Reveals How Human Cell Nucleus Organizes DNA and Chromatin of its Genome

July 27, 2017

A team of researchers at the University of California San Diego School of Medicine and the Salk Institute for Biological Studies describe development and application of new electron microscopic imaging tools and a selective stain for DNA to visualize the three-dimensional structure of chromatin — a complex of molecules that…

Pair of Discoveries Illuminate New Paths to Flu and Anthrax Treatments

October 17, 2017

Two recent studies led by UC San Diego biologists have set the research groundwork for new avenues to treat influenza and anthrax poisoning. Published in PLOS Pathogens, the studies from Professor Ethan Bier’s laboratory used a series of experiments to identify key pathways and mechanisms previously unknown or overlooked in…

Polygenic Risk Score May Identify Alzheimer’s Risk in Younger Populations

March 5, 2018

For the first time, an international team of scientists, led by researchers at University of California San Diego School of Medicine, have determined that an Alzheimer’s disease (AD) polygenic risk score can be used to correctly identify adults with mild cognitive impairment (MCI) who were only in their 50s. MCI…

Biosensor Chip Detects Single Nucleotide Polymorphism Wirelessly and With Higher Sensitivity

July 9, 2018

A team led by the University of California San Diego has developed a chip that can detect a type of genetic mutation known as a single nucleotide polymorphism (SNP) and wirelessly send the results in real time to an electronic device. The chip is at least 1,000 times more sensitive…

Neutrophil Nanosponges Soak up Proteins That Promote Rheumatoid Arthritis

September 3, 2018

Engineers have developed neutrophil “nanosponges” that can safely absorb and neutralize a variety of proteins that play a role in the progression of rheumatoid arthritis. Injections of these nanosponges effectively treated severe rheumatoid arthritis in two mouse models. Administering the nanosponges early on also prevented the disease from developing. The…

Clinical Trial to Investigate whether Hypertension Drug Ameliorates COVID-19 Severity

April 30, 2020

UC San Diego scientists have launched a clinical trial to investigate whether a drug approved for treating high blood pressure might also reduce the severity of COVID-19 infections, lowering rates for intensive care unit admissions, the use of mechanical ventilators and all-cause mortality.

Longitudinal Study of Brain Aging and Cognitive Change Receives $19 Million Grant

June 15, 2020

Researchers at UC San Diego School of Medicine, with colleagues elsewhere, will receive almost $19 million over five years for the fourth phase of the Vietnam Era Twin Study of Aging, which investigates cognition, aging and the risk for mild cognitive impairment and Alzheimer’s disease.

Scientists Use Geometry to Track Cell Migrations

December 1, 2020

Researchers from UC San Diego and UC Santa Barbara combine physics and biology to find that the physical environment where cells migrate through tight spaces is worth considering when studying conditions like development of the brain or movement of immune cells through lymph nodes and tumors.

Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer’s Disease

March 2, 2021

Researchers at UC San Diego School of Medicine and elsewhere have identified a new drug that could prevent AD by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques.

Graduate Students Honored as Siebel Scholars

September 23, 2021

Five graduate students working at the interface of engineering and medicine have been honored as 2022 Siebel Scholars. They are pursuing graduate degrees in bioengineering, electrical engineering, nanoengineering, and bioinformatics, all with a focus on advancing human health. Five graduate student

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